A mild synthesis of bis(indolyl)methanes using a deep eutectic solvent

被引：42

作者：

Handy, Scott ^{[1
]}

Westbrook, Nicole M. ^{[1
]}

机构：

[1] Middle Tennessee State Univ, Dept Chem, Murfreesboro, TN 37132 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 35期

关键词：

Organocatalysis; Condensation reaction; Deep eutectic; Indoles; EFFICIENT SYNTHESIS; INDOLYL METHANES; SULFONIC-ACID; BIS-INDOLYL; CATALYST; DERIVATIVES; METABOLITE; BACTERIUM;

D O I：

10.1016/j.tetlet.2014.07.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deep eutectic solvents (such as the combination of urea and choline chloride) are effective solvents/organocatalysts for the condensation of indole and aryl or alkenyl aldehydes to form bis(indolyl)methanes. The reaction conditions are quite mild and do not require additional Bronsted or Lewis acid catalyst, though they fail with ketones or aliphatic aldehydes. Given the inexpensive, non-toxic, and recyclable nature of the DES, these reaction conditions are simple and highly environmentally friendly. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4969 / 4971

页数：3

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