N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon-sulfur bonds

被引：46

作者：

He, Lin ^{[1
]}

Guo, Hao ^{[1
]}

Li, Yuan-Zhen ^{[1
]}

Du, Guang-Fen ^{[1
]}

Dai, Bin ^{[1
]}

机构：

[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832000, Xinjiang Uygur, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 28期

基金：

中国国家自然科学基金;

关键词：

ALPHA; BETA-UNSATURATED ALDEHYDES; ESTERS; ENALS; GENERATION; CONVERSION; ADDITIONS; UMPOLUNG; KETONES; BASE;

D O I：

10.1039/c4cc00154k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel N-heterocyclic carbene (NHC)-catalyzed formal cross-coupling reaction between alpha-haloenals and thiols was developed. In the presence of 5 mol% NHC precursors and 1.6 equiv. potassium carbonate, various thiols coupled with alpha-haloenals to produce alpha-thioenals in 53% to 91% yield and excellent Z-selectivity.

引用

页码：3719 / 3721

页数：3

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