Electrochemotherapy in the treatment of cutaneous malignancy: Outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008-2019)

被引：76

作者：

Clover, A. J. P. ^{[1
]}

de Terlizzi, F. ^{[2
]}

Bertino, G. ^{[3
]}

Curatolo, P. ^{[4
]}

Odili, J. ^{[5
]}

Campana, L. G. ^{[6
]}

Kunte, C. ^{[7
,8
]}

Muir, T. ^{[9
]}

Brizio, M. ^{[10
]}

Sersa, G. ^{[11
]}

Jones, R. Pritchard ^{[12
]}

Moir, G. ^{[13
,14
]}

Orlando, A. ^{[15
]}

Banerjee, S. M. ^{[16
]}

Kis, E. ^{[17
]}

McCaul, J. A. ^{[18
]}

Grischke, E. M. ^{[19
]}

Matteucci, P. ^{[20
]}

Mowatt, D. ^{[21
]}

Bechara, F. G. ^{[22
]}

Mascherini, M. ^{[23
]}

Lico, V ^{[24
]}

Giorgione, R. ^{[25
]}

Seccia, V ^{[26
]}

Schepler, H. ^{[27
]}

Pecorari, G. ^{[28
]}

Ross, A. D. MacKenzie ^{[29
]}

Bisase, B. ^{[30
]}

Gehl, J. ^{[31
,32
,33
]}

机构：

[1] Univ Coll Cork, Dept Plast Surg, Canc Res UCC, Western Gateway Bldg, Cork, Ireland

[2] IGEA Biophys Lab, Carpi, MO, Italy

[3] Univ Pavia, IRCCS Policlin San Matteo Fdn, Dept Otolaryngol Head Neck Surg, Pavia, Italy

[4] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, Div Dermatol, Policlin Umberto I, Rome, Italy

[5] St Georges Univ Hosp NHS Trust, Dept Plast Surg, London, England

[6] Univ Padua, Dept Surg Ontol & Gastroenterol Sci DISCOG, Padua, Italy

[7] Ludwig Maximilian Univ Munich, Dept Dermatol & Allergol, Munich, Germany

[8] Artemed Fachklin Munich, Dept Dermatol Surg & Dermatol, Munich, Germany

[9] James Cook Univ Hosp, Middlesbrough, Cleveland, England

[10] Univ Turin, Dermatol Clin, Dept Med Sci, Turin, Italy

[11] Inst Oncol Ljubljana, Dept Expt Oncol, Zaloska 2, Ljubljana, Slovenia

[12] Merseyside Plast Surg Ctr, Liverpool, Merseyside, England

[13] Royal London Hosp, Dept Cutaneous Med & Surg, London, England

[14] QMUL, Barts Hlth NHS Trust, Skin Canc SSMDT, London, England

[15] North Bristol NHS Trust, Dept Plast & Reconstruct Surg, Southmead Hosp, Bristol, Avon, England

[16] UCL, Dept Surg & Intervent Sci, Royal Free Campus, London, England

[17] Univ Szeged, Dept Dermatol & Allergol, Szeged, Hungary

[18] Queen Elizabeth Univ Hosp, Maxillofacial Unit, Glasgow, Lanark, Scotland

[19] Univ Frauenklin, Tubingen, Germany

[20] Hull Univ Teaching Hosp NHS Trust, Kingston Upon Hull, N Humberside, England

[21] Christie Hosp, Manchester, Lancs, England

[22] Ruhr Univ Bochum, Dept Dermatol Venerol & Allergol, St Josef Hosp, Bochum, Germany

[23] Univ Genoa, Osped Policlin San Martino, Clin Chirurg 1, Genoa, Italy

[24] Dept Gen Surg, Mirano, Italy

[25] Univ Piemonte Orientale, Dermatol Clin, Novara, Italy

[26] Univ Hosp Pisa, ENT Unit, Pisa, Italy

[27] Johannes Gutenberg Univ Mainz, Dept Dermatol, Mainz, Germany

[28] Univ Turin, Dept Surg Sci, Otolaryngol Clin, Turin, Italy

[29] Guys & St Thomas Hosp, Dept Plast Surg, London, England

[30] Queen Victoria Hosp NHS Fdn Trust, Clin Head & Neck Canc, E Grinstead, W Sussex, England

[31] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Oncol, Herlev, Denmark

[32] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[33] Zealand Univ Hosp, Dept Clin Oncol & Palliat Care, Roskilde, Denmark

来源：

EUROPEAN JOURNAL OF CANCER | 2020年 / 138卷

关键词：

Electrochemotherapy; Cutaneous tumours; Malignant melanoma; Breast cancer; Basal cell carcinoma; Squamous cell carcinoma; Kaposi's sarcoma; STANDARD OPERATING PROCEDURES; IN-VIVO ELECTROPORATION; INTERDISCIPLINARY GUIDELINE; BREAST-CANCER; METASTASES; BLEOMYCIN; MELANOMA; TUMORS; ELECTROPERMEABILIZATION; RECURRENCE;

D O I：

10.1016/j.ejca.2020.06.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Electrochemotherapy (ECT) is a treatment for both primary and secondary cutaneous tumours. The international Network for sharing practices on ECT group investigates treatment outcomes after ECT using a common database with defined parameters. Methods: Twenty-eight centres across Europe prospectively uploaded data over an 11-year period. Response rates were investigated in relation to primary diagnosis, tumour size, choice of electrode type, route of bleomycin administration, electrical parameters recorded and previous irradiation in the treated field. Results: Nine hundred eighty-seven patients, with 2482 tumour lesions were included in analysis. The overall response (OR) rate was 85% (complete response [CR]: 70%, partial response rate: 15%, stable disease: 11%, and progressive disease: 2%). For different histologies, OR and CR rates for metastases of malignant melanoma were 82% and 64%, basal cell carcinoma were 96% and 85%, breast cancer metastases were 77% and 62%, squamous cell carcinoma were 80% and 63% as well as Kaposi's sarcoma were 98% and 91%, respectively. Variance was demonstrated across histotypes (p < 0.0001) and in accordance with size of lesion treated (dichotomised at diameter of 3 cm (p < 0.0001). Hexagonal electrodes were generally used for larger tumours, but for tumours up to 3 cm, linear array electrodes provided better tumour control than hexagonal electrodes (80%:74%, p < 0.003). For tumours more than 2 cm, intravenous administration was superior to intratumoural (IT) administration (p < 0.05). Current recorded varied across tumour histologies and size but did not influence response rate. In previously irradiated areas, responses were selectively lower for IT administration. Conclusions: These cumulative data endorse efficiency of ECT across a broad range of histotypes. Analysis of 2482 lesions details subgroup analysis on treatment response informing future treatment choices. (C) 2020 Published by Elsevier Ltd.

引用

页码：30 / 40

页数：11

共 1 条

[1] Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: analysis of 57 patients from the International Network for Sharing Practices of Electrochemotherapy registry
Rotunno, R.
Campana, L. G.
Quaglino, P.
de Terlizzi, F.
Kunte, C.
Odili, J.
Gehl, J.
Ribero, S.
Liew, S. H.
Marconato, R.
Brizio, M.
Curatolo, P.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2018, 32 (07) : 1147 - 1154

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