A versatile approach to affinitychromic polythiophenes

被引：58

作者：

Bernier, S ^{[1
]}

Garreau, S ^{[1
]}

Béra-Abérem, M ^{[1
]}

Gravel, C ^{[1
]}

Leclerc, M ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, Ctr Rech Sci & Ingn Macromol, Canada Res Chair Electroact & Photoact Polymers, Quebec City, PQ G1K 7P4, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 42期

关键词：

D O I：

10.1021/ja027387l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of both postfunctionalizable and chromic poly[3-(N-succinimido-p-phenylcarboxylate(tetraethoxy)oxy)-4-methylthiophene] is reported. The N-hydroxysuccinimide ester side group can easily react with different amine-bearing molecules in the solid state to yield a library of new polythiophene derivatives. The resulting polymers can be dissolved in various solvents, and interactions between the side chains (ligands) and different analytes (targets) can be detected from modifications of both the side-chain and the backbone conformations resulting in important color changes (i.e., affinitychromism). This colorimetric polymeric transducer could therefore lead to highly valuable, versatile, and inexpensive tools for highthroughput screening and drug discovery.

引用

页码：12463 / 12468

页数：6

共 33 条

[1] Concentration-dependent thermochromism and supramolecular aggregation in solution of triblock copolymers based on lengthy oligothiophene cores and poly(benzyl ether) dendrons [J].