Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties:: a review

被引:151
作者
Bagalkotkar, G.
Sagineedu, S. R.
Saad, M. S.
Stanslas, J. [1 ]
机构
[1] Univ Putra Malaysia, Dept Biomed Sci, Fac Med & Hlth Sci, Serdang 43400, Malaysia
[2] Univ Putra Malaysia, Dept Plant Sci, Fac Agr, Serdang 43400, Malaysia
[3] Univ Putra Malaysia, Lab Nat Prod, Inst Biosci, Serdang 43400, Malaysia
关键词
D O I
10.1211/jpp.58.12.0001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri. Extracts of this herb have been proven to have therapeutic effects in many clinical studies. Some of the most intriguing therapeutic properties include anti-hepatotoxic, anti-lithic, anti-hypertensive, anti-HIV and anti-hepatitis B. Therefore, studies relating to chemical characteristics and structural properties of the bioactive phytochemicals found in P. niruri are very useful for further research on this plant as many of the phytochemicals have shown preclinical therapeutic efficacies for a wide range of human diseases, including HIV/ AIDS and hepatitis B.
引用
收藏
页码:1559 / 1570
页数:12
相关论文
共 114 条
[1]   Synthesis and characterisation of some water soluble ruthenium(II)-arene complexes and an investigation of their antibiotic and antiviral properties [J].
Allardyce, CS ;
Dyson, PJ ;
Ellis, DJ ;
Salter, PA ;
Scopelliti, R .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2003, 668 (1-2) :35-42
[2]   CRYSTALLINE CONSTITUENTS OF EUPHORBIACEAE .12. ISOLATION AND STRUCTURAL ELUCIDATION OF 3 NEW LIGNANS FROM LEAVES OF PHYLLANTHUS-NIRURI LINN [J].
ANJANEYULU, AS ;
RAO, KJ ;
SUBRAHMANYAM, C ;
ROW, LR .
TETRAHEDRON, 1973, 29 (10) :1291-1298
[3]   Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine isolated left anterior descending coronary artery by diosgenin [J].
Au, ALS ;
Kwok, CC ;
Lee, ATC ;
Kwan, YW ;
Lee, MMS ;
Zhang, RZ ;
Ngai, SM ;
Lee, SMY ;
He, GW ;
Fung, KP .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 502 (1-2) :123-133
[4]   Effects of an aqueous extract from Phyllanthus niruri on calcium oxalate crystallization in vitro [J].
Barros, ME ;
Schor, N ;
Boim, MA .
UROLOGICAL RESEARCH, 2003, 30 (06) :374-379
[5]  
BECKER CG, 1985, AM J PATHOL, V120, P1
[6]   SECURININE ALKALOIDS - A NEW CLASS OF GABA RECEPTOR ANTAGONIST [J].
BEUTLER, JA ;
KARBON, EW ;
BRUBAKER, AN ;
MALIK, R ;
CURTIS, DR ;
ENNA, SJ .
BRAIN RESEARCH, 1985, 330 (01) :135-140
[7]   The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties [J].
Bhattacharjee, Rajesh ;
Sil, Parames C. .
PHYTOTHERAPY RESEARCH, 2006, 20 (07) :595-601
[8]  
BUNYAPRAPHATSAR.N, 1983, 24 ANN M AM SOC PHAR, P24
[9]  
BURKILL IH, 1996, DICT EC PRODUCTS MAL, P1748
[10]  
CALIXTO JB, 1984, BRAZ J MED BIOL RES, V17, P313