A Novel Marmoset (Callithrix jacchus) Model of Human Inhalational Q Fever

被引:9
作者
Nelson, Michelle [1 ]
Salguero, Francisco J. [2 ]
Hunter, Laura [2 ]
Atkins, Timothy P. [1 ]
机构
[1] Def Sci & Technol Lab Dstl, CBR Div, Salisbury, Wilts, England
[2] Publ Hlth England, Salisbury, Wilts, England
来源
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 10卷
关键词
nonhuman primate; infectious disease; histology; innate immunology; Coxiella burnetii; COXIELLA-BURNETII INFECTION; ANIMAL-MODELS; RISK-FACTORS; DIAGNOSIS; RESPONSES; EXPOSURE; MONKEYS; NETHERLANDS; OUTBREAK; EFFICACY;
D O I
10.3389/fcimb.2020.621635
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Common marmosets (Callithrix jacchus) were shown to be susceptible to inhalational infection with Coxiella burnetii, in a dose-dependent manner, producing a disease similar to human Q fever, characterized by a resolving febrile response. Illness was also associated with weight loss, liver enzyme dysfunction, characteristic cellular activation, circulating INF-gamma and bacteraemia. Viable C. burnetii was recovered from various tissues during disease and from 75% of the animal's lungs on 28 days post challenge, when there were no overt clinical features of disease but there was histological evidence of macrophage and lymphocyte infiltration into the lung resulting in granulomatous alveolitis. Taken together, these features of disease progression, physiology and bacterial spread appear to be consistent with human disease and therefore the common marmoset can be considered as a suitable model for studies on the pathogenesis or the development of medical counter measures of inhalational Q fever.
引用
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页数:12
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