Common marmosets (Callithrix jacchus) were shown to be susceptible to inhalational infection with Coxiella burnetii, in a dose-dependent manner, producing a disease similar to human Q fever, characterized by a resolving febrile response. Illness was also associated with weight loss, liver enzyme dysfunction, characteristic cellular activation, circulating INF-gamma and bacteraemia. Viable C. burnetii was recovered from various tissues during disease and from 75% of the animal's lungs on 28 days post challenge, when there were no overt clinical features of disease but there was histological evidence of macrophage and lymphocyte infiltration into the lung resulting in granulomatous alveolitis. Taken together, these features of disease progression, physiology and bacterial spread appear to be consistent with human disease and therefore the common marmoset can be considered as a suitable model for studies on the pathogenesis or the development of medical counter measures of inhalational Q fever.
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ANDERSON A, 2013, MMWR-MORBID MORTAL W, V62, P1
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Bae, Moonsuk
Jin, Choong Eun
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr,Dept Convergence Med, 88,Olymp Ro 43 Gil, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Jin, Choong Eun
Park, Joung Ha
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Park, Joung Ha
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Kim, Min Jae
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Chong, Yong Pil
Lee, Sang-Oh
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Lee, Sang-Oh
Choi, Sang-Ho
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Choi, Sang-Ho
Kim, Yang Soo
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Kim, Yang Soo
Woo, Jun Hee
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Woo, Jun Hee
Shin, Yong
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr,Dept Convergence Med, 88,Olymp Ro 43 Gil, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Shin, Yong
Kim, Sung-Han
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
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Birmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Royal Ctr Def Med, Dept Mil Med, Birmingham, W Midlands, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Bailey, M. S.
Trinick, T. R.
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204 N Irish Field Hosp RAMC V, Belfast, Antrim, North IrelandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Trinick, T. R.
Dunbar, J. A.
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212 Yorkshire Field Hosp RAMC V, Sheffield, S Yorkshire, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Dunbar, J. A.
Hatch, R.
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Royal Hosp Haslar, Pathol Labs, Gosport, Hants, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Hatch, R.
Osborne, J. C.
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HPA Porton Down, Special Pathogens Reference Unit, Salisbury, Wilts, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Osborne, J. C.
Brooks, T. J.
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HPA Porton Down, Special Pathogens Reference Unit, Salisbury, Wilts, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Brooks, T. J.
Green, A. D.
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Royal Ctr Def Med, DCA Communicable Dis, Birmingham, W Midlands, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Brooke, Russell John
Kretzschmar, Mirjam E. E.
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
RIVM, Ctr Infect Dis Control, Bilthoven, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Kretzschmar, Mirjam E. E.
Mutters, Nico T.
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Univ Heidelberg Hosp, Dept Infect Dis Med Microbiol & Hyg, Heidelberg, GermanyUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
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Teunis, Peter F.
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RIVM, Ctr Infect Dis Control, Bilthoven, Netherlands
Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USAUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
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Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA
Texas Biomed Res Inst, SW Natl Primate Res Ctr, San Antonio, TX 78227 USATexas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA
Carrion, Ricardo, Jr.
Patterson, Jean L.
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Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USATexas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Bae, Moonsuk
Jin, Choong Eun
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr,Dept Convergence Med, 88,Olymp Ro 43 Gil, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Jin, Choong Eun
Park, Joung Ha
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Park, Joung Ha
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Kim, Min Jae
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Chong, Yong Pil
Lee, Sang-Oh
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Lee, Sang-Oh
Choi, Sang-Ho
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Choi, Sang-Ho
Kim, Yang Soo
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Kim, Yang Soo
Woo, Jun Hee
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Woo, Jun Hee
Shin, Yong
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr,Dept Convergence Med, 88,Olymp Ro 43 Gil, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
Shin, Yong
Kim, Sung-Han
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Univ Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Inst Convergence Sci & Technol, Dept Infect Dis,Asan Med Ctr, Seoul, South Korea
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Birmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Royal Ctr Def Med, Dept Mil Med, Birmingham, W Midlands, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Bailey, M. S.
Trinick, T. R.
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204 N Irish Field Hosp RAMC V, Belfast, Antrim, North IrelandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Trinick, T. R.
Dunbar, J. A.
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212 Yorkshire Field Hosp RAMC V, Sheffield, S Yorkshire, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Dunbar, J. A.
Hatch, R.
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Royal Hosp Haslar, Pathol Labs, Gosport, Hants, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Hatch, R.
Osborne, J. C.
论文数: 0引用数: 0
h-index: 0
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HPA Porton Down, Special Pathogens Reference Unit, Salisbury, Wilts, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Osborne, J. C.
Brooks, T. J.
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机构:
HPA Porton Down, Special Pathogens Reference Unit, Salisbury, Wilts, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
Brooks, T. J.
Green, A. D.
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Royal Ctr Def Med, DCA Communicable Dis, Birmingham, W Midlands, EnglandBirmingham Heartlands Hosp, Dept Infect & Trop Med, Birmingham B9 5ST, W Midlands, England
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Brooke, Russell John
Kretzschmar, Mirjam E. E.
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h-index: 0
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
RIVM, Ctr Infect Dis Control, Bilthoven, NetherlandsUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Kretzschmar, Mirjam E. E.
Mutters, Nico T.
论文数: 0引用数: 0
h-index: 0
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Univ Heidelberg Hosp, Dept Infect Dis Med Microbiol & Hyg, Heidelberg, GermanyUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Mutters, Nico T.
Teunis, Peter F.
论文数: 0引用数: 0
h-index: 0
机构:
RIVM, Ctr Infect Dis Control, Bilthoven, Netherlands
Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USAUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
机构:
Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA
Texas Biomed Res Inst, SW Natl Primate Res Ctr, San Antonio, TX 78227 USATexas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA
Carrion, Ricardo, Jr.
Patterson, Jean L.
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h-index: 0
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Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USATexas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA