Bone Disease in Mastocytosis

被引：31

作者：

Orsolini, Giovanni ^{[1
]}

Viapiana, Ombretta ^{[1
]}

Rossini, Maurizio ^{[1
]}

Bonifacio, Massimiliano ^{[2
]}

Zanotti, Roberta ^{[2
]}

机构：

[1] Univ Verona, Rheumatol Unit, Verona, Italy

[2] Univ Verona, Hematol Unit, Verona, Italy

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2018年 / 38卷 / 03期

关键词：

Mastocytosis; Osteoporosis; Osteosclerosis; Fracture; Bone mineral density; Bone turnover markers; INDOLENT SYSTEMIC MASTOCYTOSIS; MAST-CELL DISEASE; SERUM-LEVELS; RETROSPECTIVE ANALYSIS; HISTAMINE-RECEPTORS; INTERFERON-ALPHA; OSTEOPOROSIS; FRACTURES; RISK; PAMIDRONATE;

D O I：

10.1016/j.iac.2018.04.013

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinically relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures. The main factor of bone loss is the osteoclast with a relative or absolute predominance of bone resorption. The RANK-RANKL pathway seems of key importance, but histamine and other cytokines also play a significant role in the process. The predominance of resorption made bisphosphonates, as antiresorptive drugs, the most rational treatment of bone involvement in systemic mastocytosis.

引用

页码：443 / +

页数：13

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