Synthesis of gold nanorod-embedded polymeric nanoparticles by a nanoprecipitation method for use as photothermal agents

被引：48

作者：

Kim, Eunjung ^{[2
]}

Yang, Jaemoon ^{[1
]}

Choi, Jihye ^{[2
]}

Suh, Jin-Suck ^{[1
]}

Huh, Yong-Min ^{[1
]}

Haam, Seungjoo ^{[2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Engn, Dept Chem & Biomol Engn, Seoul 120749, South Korea

来源：

NANOTECHNOLOGY | 2009年 / 20卷 / 36期

关键词：

THERAPY; CELL; NANOHYBRIDS; SINGLE; GROWTH;

D O I：

10.1088/0957-4484/20/36/365602

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

For the synthesis of biocompatible photothermal agents, gold nanorod-embedded polymeric nanoparticles (GPNs) were synthesized using a nanoprecipitation method. Uniform gold nanorods (GNRs), which are sensitive to a photothermal effect by near-infrared (NIR) light, with an aspect ratio of 4.0 were synthesized by a seed-mediated growth method. The hydroxyl groups of polycaprolactone diol (PCL diOH) were modified by esterification with mercaptopropionic acid to give a dithiol (polycaprolactone dithiol, PCL diSH) as a phase transfer and capping agent. Subsequently, hexadecyltrimethylammonium bromide (CTAB), a stabilizer of GNRs, was exchanged and/or removed by PCL diSH. PCL diSH-coated GNRs were further wrapped in a hydrophilic polymer, Pluronic F127, as a stabilizer. These newly formulated GPNs exhibit excellent stability in water and a maximum absorbance in the NIR region indicating a highly efficient surface plasmon resonance effect, phenomena useful for photothermal agents.

引用

页数：7

共 29 条

[1] Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects [J].

Alkilany, Alaaldin M. ;

Nagaria, Pratik K. ;

Hexel, Cole R. ;

Shaw, Timothy J. ;

Murphy, Catherine J. ;

Wyatt, Michael D. .

SMALL, 2009, 5 (06) :701-708

[2] Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles [J].

Bilati, U ;

Allémann, E ;

Doelker, E .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2005, 24 (01) :67-75

[3] Thermal ablation of tumor cells with anti body-functionalized single-walled carbon nanotubes [J].

Chakravarty, Pavitra ;

Marches, Radu ;

Zimmerman, Neil S. ;

Swafford, Austin D. -E. ;

Bajaj, Pooja ;

Musselman, Inga H. ;

Pantano, Paul ;

Draper, Rockford K. ;

Vitetta, Ellen S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (25) :8697-8702

[4] The potential environmental impact of engineered nanomaterials [J].

Colvin, VL .

NATURE BIOTECHNOLOGY, 2003, 21 (10) :1166-1170

[5] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].

Connor, EE ;

Mwamuka, J ;

Gole, A ;

Murphy, CJ ;

Wyatt, MD .

SMALL, 2005, 1 (03) :325-327

[6] Arrhenius relationships from the molecule and cell to the clinic [J].

Dewey, W. C. .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2009, 25 (01) :3-20

[7] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

[8] Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods [J].

Huang, XH ;

El-Sayed, IH ;

Qian, W ;

El-Sayed, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) :2115-2120

[9] Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction [J].

Kam, NWS ;

O'Connell, M ;

Wisdom, JA ;

Dai, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) :11600-11605

[10] Red photoluminescence of gold island films [J].

Khriachtchev, L ;

Heikkilä, L ;

Kuusela, T .

APPLIED PHYSICS LETTERS, 2001, 78 (14) :1994-1996

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