Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase

被引：109

作者：

Ueno, T ^{[1
]}

Ohtawa, K ^{[1
]}

Mitsui, K ^{[1
]}

Kodera, Y ^{[1
]}

Hiroto, M ^{[1
]}

Matsushima, A ^{[1
]}

Inada, Y ^{[1
]}

Nishimura, H ^{[1
]}

机构：

[1] TOIN UNIV YOKOHAMA,DEPT MAT SCI & TECHNOL,TOIN HUMAN SCI & TECHNOL CTR,AOBA KU,YOKOHAMA,KANAGAWA 225,JAPAN

来源：

LEUKEMIA | 1997年 / 11卷 / 11期

关键词：

L-asparaginase; apoptosis; cell cycle; G1; arrest; leukemia;

D O I：

10.1038/sj.leu.2400834

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apoptotic cell death of murine leukemia cells induced by E. coli L-asparaginase was studied. Deprivation of L-asparagine from the culture of L5178Y cells by L-asparaginase caused the fragmentation of chromosomal DNA of the leukemia cells within 24 h. Prior to the degradation of DNA, cell cycles of L5178Y cells were found to be arrested in G1 phase, and evidence of the DNA strand breaks was initially observed in G1 phase cells as early as 8 h after the asparaginase treatment. Therefore, apoptosis of leukemia cells induced by L-asparaginase is an event that is associated with the cell cycle arrest in G1 phase.

引用

页码：1858 / 1861

页数：4

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