Shedding Light on Living Cells

被引:32
作者
Antognazza, Maria Rosa [1 ]
Martino, Nicola [1 ,2 ]
Ghezzi, Diego [3 ]
Feyen, Paul [3 ]
Colombo, Elisabetta [1 ,3 ]
Endeman, Duco [3 ]
Benfenati, Fabio [3 ]
Lanzani, Guglielmo [1 ,2 ]
机构
[1] PoliMi, Ist Italiano Tecnol, Ctr Nano Sci & Technol, I-20133 Milan, Italy
[2] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy
[3] Ist Italiano Tecnol, Neurosci & Brain Technol Dept, I-16163 Genoa, Italy
关键词
RESTORING VISUAL FUNCTION; LASER STIMULATION; OPTICAL CONTROL; ELECTRICAL-STIMULATION; REMOTE-CONTROL; ION CHANNELS; NEURONS; PHOTOSTIMULATION; INTERFACE; RAT;
D O I
10.1002/adma.201403513
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An overview of the optical methods available to modulate the cellular activity in cell cultures and biological tissues is presented, with a focus on the use of exogenous functional materials that absorb electromagnetic radiation and transduce it into a secondary stimulus for cell excitation, with high temporal and spatial resolution. Both organic and inorganic materials are critically evaluated, for in vitro and in vivo applications. Finally, as a direct practical application of optical-stimulation techniques, the most recent results in the realization of artificial visual implants are discussed.
引用
收藏
页码:7662 / 7669
页数:8
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