Synthesis and biological activity of Akt/PI3K inhibitors

被引：15

作者：

Redaelli, C. ^{[1
]}

Granucci, F. ^{[1
]}

De Gioia, L. ^{[1
]}

Cipolla, L. ^{[1
]}

机构：

[1] Univ Milan, Dept Biosci & Biotechnol, I-20126 Milan, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 10期

关键词：

kinases; Akt; PI3K; cancer; kinase inhibitors; allosteric inhibitors; phosphatidylinositol; phosphatidylinositol analogues;

D O I：

10.2174/138955706778560139

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.

引用

页码：1127 / 1136

页数：10

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