Synthesis and biological activity of Akt/PI3K inhibitors

被引：15
|
作者：
Redaelli, C. [1 ]
Granucci, F. [1 ]
De Gioia, L. [1 ]
Cipolla, L. [1 ]
机构：
[1] Univ Milan, Dept Biosci & Biotechnol, I-20126 Milan, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 10期
关键词：
kinases; Akt; PI3K; cancer; kinase inhibitors; allosteric inhibitors; phosphatidylinositol; phosphatidylinositol analogues;
D O I：
10.2174/138955706778560139
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.
引用
收藏
页码：1127 / 1136
页数：10
相关论文
共 50 条
  • [1] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
    Huemer F.
    Bartsch R.
    Gnant M.
    Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70
  • [2] Synthesis and Biological Activity of Novel PI3K/mTOR Inhibitors
    Wang Lei
    Zheng Guojun
    Ji Qi
    Chen Bo
    Gong Longlong
    Gao Congmin
    Du Zhenjian
    Zhang Xingmin
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2017, 38 (09): : 1590 - 1595
  • [3] PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside
    Alzahrani, Ali S.
    SEMINARS IN CANCER BIOLOGY, 2019, 59 : 125 - 132
  • [4] Status of PI3K/Akt/mTOR Pathway Inhibitors in Lymphoma
    Westin, Jason R.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2014, 14 (05) : 335 - 342
  • [5] PI3K and AKT: Unfaithful Partners in Cancer
    Faes, Seraina
    Dormond, Olivier
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (09): : 21138 - 21152
  • [6] Inhibitors of the PI3K/AKT/mTOR pathway in human malignancies; trend of current clinical trials
    Davoodi-Moghaddam, Zeinab
    Jafari-Raddani, Farideh
    Delshad, Mahda
    Pourbagheri-Sigaroodi, Atieh
    Bashash, Davood
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (16) : 15293 - 15310
  • [7] The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
    Kma, Lakhan
    Baruah, Taranga Jyoti
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2022, 69 (01) : 248 - 264
  • [8] Targeting PI3K/AKT/mTOR network for treatment of leukemia
    Bertacchini, Jessika
    Heidari, Nazanin
    Mediani, Laura
    Capitani, Silvano
    Shahjahani, Mohammad
    Ahmadzadeh, Ahmad
    Saki, Najmaldin
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (12) : 2337 - 2347
  • [9] PI3K/AKT/mTOR Inhibitors In Ovarian Cancer
    Mazzoletti, M.
    Broggini, M.
    CURRENT MEDICINAL CHEMISTRY, 2010, 17 (36) : 4433 - 4447
  • [10] Identification of Potential Kinase Inhibitors within the PI3K/AKT Pathway of Leishmania Species
    Ochoa, Rodrigo
    Ortega-Pajares, Amaya
    Castello, Florencia A.
    Serral, Federico
    Fernandez Do Porto, Dario
    Villa-Pulgarin, Janny A.
    Varela-M, Ruben E.
    Muskus, Carlos
    BIOMOLECULES, 2021, 11 (07)
12345