共 81 条
Recent Development of Coumarin Derivatives as Potential Antiplasmodial and Antimalarial Agents
被引:43
作者:
Hu, Xin-Liang
[1
]
Gao, Chuan
[2
]
Xu, Zhi
[3
]
Liu, Ming-Liang
[4
,5
]
Feng, Lian-Shun
[2
]
Zhang, Guang-De
[6
]
机构:
[1] Hubei Engn Univ, Sch Chem & Mat Sci, Xiaogan, Hubei, Peoples R China
[2] WuXi AppTec, Wuhan, Hubei, Peoples R China
[3] Wuhan Univ Sci & Technol, Key Lab Hubei Prov Coal Convers & New Carbon Mat, Wuhan, Hubei, Peoples R China
[4] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[5] Peking Union Med Coll, Beijing 100050, Peoples R China
[6] Wuhan Univ Sci & Technol, Sch Automobile & Traff Engn, Wuhan, Hubei, Peoples R China
关键词:
Malaria;
plasmodium;
coumarin;
hybrid compounds;
structure-activity relationship;
antiplasmodial;
MOLECULAR DOCKING;
QUINAZOLINE DERIVATIVES;
BIOLOGICAL EVALUATION;
DRUG DISCOVERY;
ISATIN HYBRIDS;
DESIGN;
ROOTS;
CIPROFLOXACIN;
CONSTITUENTS;
ANTIBACTERIAL;
D O I:
10.2174/1568026618666171215101158
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Malaria still remains one of the leading deadliest diseases throughout the world, leading to around 1 million deaths annually. The emergence and spread of growing resistance to the first-line antimalarials are an alarming the serious problem in malaria control, demanding the need for new drugs more potent than earlier with improved Absorption, Distribution, Metabolism, and Excretion (ADME) profiles. Coumarins, which exhibited various biological properties, also displayed potential in vitro antiplasmodial and in vivo antimalarial activities. Moreover, many of coumarin derivatives have already been used in clinical practice for the treatment of several diseases. Therefore, coumarin derivatives play a pivotal role in medicinal chemistry, also making them promising candidates for the treatment of malaria. This review aims to summarize the recent advances made towards the development of coumarin-containing derivatives as antiplasmodial and antimalarial agents and their structure-activity relationship is also discussed.
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页码:114 / 123
页数:10
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