New Approach to the Synthesis of Biologically Active Derivatives of Pyranocoumarins

被引：0

作者：

Inyutina, A. K. ^{[1
]}

Fatykhov, R. F. ^{[1
]}

Khalymbadzha, I. A. ^{[1
,2
]}

Sharapov, A. D. ^{[1
]}

Bobkina, M., V ^{[1
]}

Chupakhin, O. N. ^{[1
,2
]}

机构：

[1] Ural Fed Univ, Dept Organ & Biomol Chem, Mira 19, Ekaterinburg 620002, Russia

[2] Russian Acad Sci, Inst Organ Synth, Ural Branch, Kovalevskoy 22, Ekaterinburg 620219, Russia

来源：

PROCEEDINGS OF THE II INTERNATIONAL CONFERENCE: MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2018) | 2019年 / 2063卷

基金：

俄罗斯科学基金会;

关键词：

COUMARINS;

D O I：

10.1063/1.5087351

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Operationally simple and convenient synthesis of selectively protected derivatives of 5,7-dihydroxycoumarins was proposed. The proposed method is based on the reaction of the coumarins with nicotinoyl azide yielding 7-nicotinoyloxy derivatives of the coumarins. This approach can significantly improve the procedure for preparing the dimethylpyranocoumarins, an important semiproduct for synthesis of anti-HIV agents.

引用

页数：4

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