Genomic Epidemiology of Salmonella enterica Serotype Enteritidis based on Population Structure of Prevalent Lineages

被引：67

作者：

Deng, Xiangyu ^{[1
]}

Desai, Prerak T. ^{[2
]}

den Bakker, Henk C. ^{[3
]}

Mikoleit, Matthew ^{[4
]}

Tolar, Beth ^{[4
]}

Trees, Eija ^{[4
]}

Hendriksen, Rene S. ^{[5
]}

Frye, Jonathan G. ^{[6
]}

Porwollik, Steffen ^{[2
]}

Weimer, Bart C. ^{[7
]}

Wiedmann, Martin ^{[3
]}

Weinstock, George M. ^{[8
]}

Fields, Patricia I. ^{[4
]}

McClelland, Michael ^{[2
]}

机构：

[1] Univ Georgia, Griffin, GA 30223 USA

[2] Univ Calif Irvine, Irvine, CA USA

[3] Cornell Univ, Ithaca, NY USA

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

[5] Tech Univ Denmark, DK-2800 Lyngby, Denmark

[6] USDA, Athens, GA USA

[7] Univ Calif Davis, Davis, CA 95616 USA

[8] Washington Univ, Sch Med, St Louis, MO USA

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 09期

基金：

美国国家卫生研究院;

关键词：

TANDEM REPEAT ANALYSIS; EVOLUTIONARY; SELECTION; OUTBREAK; ORIGINS; MODEL;

D O I：

10.3201/eid2009.131095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Salmonella enterica serotype Enteritidis is one of the most commonly reported causes of human salmonellosis. Its low genetic diversity, measured by fingerprinting methods, has made subtyping a challenge. We used whole-genome sequencing to characterize 125 S. enterica Enteritidis and 3 S. enterica serotype Nitra strains. Single-nucleotide polymorphisms were filtered to identify 4,887 reliable loci that distinguished all isolates from each other. Our whole-genome single-nucleotide polymorphism typing approach was robust for S. enterica Enteritidis subtyping with combined data for different strains from 2 different sequencing platforms. Five major genetic lineages were recognized, which revealed possible patterns of geographic and epidemiologic distribution. Analyses on the population dynamics and evolutionary history estimated that major lineages emerged during the 17th-18th centuries and diversified during the 1920s and 1950s.

引用

页码：1481 / 1489

页数：9

共 40 条

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