A [4+3] annulation of benzofuran-derived azadienes and α-bromohydroxamates for the synthesis of benzofuran-fused 1,4-diazepinones

被引：18

作者：

Fang, Qing-Yun ^{[1
]}

Zhao, Li-Ming ^{[1
,2
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 90期

关键词：

ENANTIOSELECTIVE SYNTHESIS; AZAOXYALLYL CATIONS; CYCLOADDITION; CONSTRUCTION; HETEROCYCLES; DERIVATIVES; IMINES;

D O I：

10.1039/d0cc06061e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Cs2CO3-mediated formal [4+3] cycloaddition involving benzofuran-derived azadienes (BDAs) and alpha-bromohydroxamates to afford benzofuran-fused 1,4-diazepinones is established. This is the first example of using BDAs for the construction of seven-membered dinitrogen-fused heterocycles. This strategy not only enriches the chemistry of BDAs but also provides an interesting class of bioisosteres of 1,4-benzodiazepine.

引用

页码：14079 / 14082

页数：4

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