Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

被引：27

作者：

Tian, Yanli ^{[1
,2
]}

Zhang, Xueli ^{[1
,3
,4
]}

Li, Yuyan ^{[1
,3
]}

Shoup, Timothy M. ^{[5
]}

Teng, Xin ^{[5
]}

Elmaleh, David R. ^{[5
]}

Moore, Anna ^{[1
]}

Ran, Chongzhao ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Mol Imaging Lab,AA Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510275, Guangdong, Peoples R China

[3] China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China

[4] Southeast Univ, ZhongDa Hosp, Dept Pharm, Nanjing, Jiangsu, Peoples R China

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Nucl Med & Mol Imaging,Dept Radiol, Boston, MA USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 99期

关键词：

MOLECULAR RECOGNITION; PEPTIDE; FIBRILS; BINDING; MECHANISM; OLIGOMERS;

D O I：

10.1039/c4cc06029f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this report, we reasoned that non-covalent modification of amyloid beta (Ab) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Ab plaques and CAAs in AD mice.

引用

页码：15792 / 15795

页数：4

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