Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

被引：27
|
作者：
Tian, Yanli [1 ,2 ]
Zhang, Xueli [1 ,3 ,4 ]
Li, Yuyan [1 ,3 ]
Shoup, Timothy M. [5 ]
Teng, Xin [5 ]
Elmaleh, David R. [5 ]
Moore, Anna [1 ]
Ran, Chongzhao [1 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Mol Imaging Lab,AA Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510275, Guangdong, Peoples R China
[3] China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China
[4] Southeast Univ, ZhongDa Hosp, Dept Pharm, Nanjing, Jiangsu, Peoples R China
[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Nucl Med & Mol Imaging,Dept Radiol, Boston, MA USA
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 99期
关键词：
MOLECULAR RECOGNITION; PEPTIDE; FIBRILS; BINDING; MECHANISM; OLIGOMERS;
D O I：
10.1039/c4cc06029f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this report, we reasoned that non-covalent modification of amyloid beta (Ab) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Ab plaques and CAAs in AD mice.
引用
收藏
页码：15792 / 15795
页数：4
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