Post kala-azar dermal leishmaniasis: an unresolved mystery

被引：98
|
作者：
Mukhopadhyay, Debanjan [1 ]
Dalton, Jane E. [2 ,3 ]
Kaye, Paul M. [2 ,3 ]
Chatterjee, Mitali [1 ]
机构：
[1] Postgrad Inst Med Educ & Res, Dept Pharmacol, Kolkata 700020, India
[2] Univ York, Hull York Med Sch, Ctr Immunol & Infect, York YO10 5DD, N Yorkshire, England
[3] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England
来源：
TRENDS IN PARASITOLOGY | 2014年 / 30卷 / 02期
基金：
英国医学研究理事会;
关键词：
ULTRAVIOLET-B RADIATION; SLC11A1 FORMERLY NRAMP1; NECROSIS-FACTOR-ALPHA; VISCERAL LEISHMANIASIS; CUTANEOUS LEISHMANIASIS; GENETIC SUSCEPTIBILITY; AMPHOTERICIN-B; VITAMIN-D; INFECTIOUS-DISEASE; LANGERHANS CELLS;
D O I：
10.1016/j.pt.2013.12.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Post kala-azar dermal leishmaniasis (PKDL), a cutaneous sequela of visceral leishmaniasis (VI), develops in some patients alongside but more commonly after apparent cure from VL. In view of the pivotal role of PKDL patients in the transmission of VL, here we review clinical, epidemiological, parasitological, and immunological perspectives of this disease, focusing on five hypotheses to explain the development of PKDL: (i) the role of antimonial drugs; (ii) UV-induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (v) genetic susceptibility of the host. This review will enable researchers and clinicians to explore the unresolved mystery of PKDL and provide a framework for future application of 'omic' approaches for the control and eventual elimination of VI.
引用
收藏
页码：65 / 74
页数：10
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