TGF-β, a 'double agent' in the immune pathology war

被引：67

作者：

Cua, DJ ^{[1
]}

Kastelein, RA ^{[1
]}

机构：

[1] Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 06期

关键词：

D O I：

10.1038/ni0606-557

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper cells that produce interleukin 17 can promote a range of immune-mediated inflammatory diseases. Papers in Nature and Immunity suggest transforming growth factor-beta promotes the differentiation of these pathogenic cells.

引用

页码：557 / 559

页数：4

共 12 条

[1]

BETTELLI E, 2006, NATURE 0430

[2] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain [J].

Cua, DJ ;

Sherlock, J ;

Chen, Y ;

Murphy, CA ;

Joyce, B ;

Seymour, B ;

Lucian, L ;

To, W ;

Kwan, S ;

Churakova, T ;

Zurawski, S ;

Wiekowski, M ;

Lira, SA ;

Gorman, D ;

Kastelein, RA ;

Sedgwick, JD .

NATURE, 2003, 421 (6924) :744-748

[3] The role of interleukin-12 in human infectious diseases: only a faint signature [J].

Fieschi, C ;

Casanova, JL .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (06) :1461-1464

[4] Cutting edge:: Roles of toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection [J].

Happel, KI ;

Zheng, MQ ;

Young, E ;

Quinton, LJ ;

Lockhart, E ;

Ramsay, AJ ;

Shellito, JE ;

Schurr, JR ;

Bagby, GJ ;

Nelson, S ;

Kolls, JK .

JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4432-4436

[5] Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages [J].

Harrington, LE ;

Hatton, RD ;

Mangan, PR ;

Turner, H ;

Murphy, TL ;

Murphy, KM ;

Weaver, CT .

NATURE IMMUNOLOGY, 2005, 6 (11) :1123-1132

[6] IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].

Langrish, CL ;

Chen, Y ;

Blumenschein, WM ;

Mattson, J ;

Basham, B ;

Sedgwick, JD ;

McClanahan, T ;

Kastelein, RA ;

Cua, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240

[7]

MANGAN PR, 2006, NATURE 0430

[8] Divergent pro- and Antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation [J].

Murphy, CA ;

Langrish, CL ;

Chen, Y ;

Blumenschein, C ;

McClanahan, T ;

Kastelein, RA ;

Sedgwick, JD ;

Cua, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) :1951-1957

[9] Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 [J].

Oppmann, B ;

Lesley, R ;

Blom, B ;

Timans, JC ;

Xu, YM ;

Hunte, B ;

Vega, F ;

Yu, N ;

Wang, J ;

Singh, K ;

Zonin, F ;

Vaisberg, E ;

Churakova, T ;

Liu, MR ;

Gorman, D ;

Wagner, J ;

Zurawski, S ;

Liu, YJ ;

Abrams, JS ;

Moore, KW ;

Rennick, D ;

de Waal-Malefyt, R ;

Hannum, C ;

Bazan, JF ;

Kastelein, RA .

IMMUNITY, 2000, 13 (05) :715-725

[10] A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 [J].

Park, H ;

Li, ZX ;

Yang, XO ;

Chang, SH ;

Nurieva, R ;

Wang, YH ;

Wang, Y ;

Hood, L ;

Zhu, Z ;

Tian, Q ;

Dong, C .

NATURE IMMUNOLOGY, 2005, 6 (11) :1133-1141

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