Exploiting Common Genetic Variation to Make Anticoagulation Safer

被引:15
作者
Chang, Yuchiao [1 ]
Cortellini, Lynelle [1 ]
Greenberg, Steven M. [1 ]
Rosand, Jonathan [1 ]
Singer, Daniel [1 ]
Schwab, Kristen [1 ]
Selim, Magdy [2 ]
Meschia, James [3 ]
Eckman, Mark H. [4 ]
Silliman, Scott [5 ]
Brown, Devon [6 ]
Worrall, W. Bradford [7 ]
Tirschwell, David [8 ]
Gage, Brian F. [9 ]
机构
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[3] Mayo Clin, Jacksonville, FL 32224 USA
[4] Univ Cincinnati, Cincinnati, OH 45221 USA
[5] Univ Florida, Gainesville, FL 32611 USA
[6] Univ Michigan, Ann Arbor, MI 48109 USA
[7] Univ Virginia, Charlottesville, VA 22903 USA
[8] Univ Washington, Seattle, WA 98195 USA
[9] Washington Univ, St Louis, MO 63130 USA
关键词
anticoagulation; ATRIAL-FIBRILLATION; CYTOCHROME P450CYP2C9-ASTERISK-2; CYP2C9-ASTERISK-3; ALLELES; HEMORRHAGIC COMPLICATIONS; INTRACEREBRAL HEMORRHAGE; BLEEDING COMPLICATIONS; WARFARIN THERAPY; RISK; CYP2C9; POLYMORPHISMS;
D O I
10.1161/STROKEAHA.108.533190
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:S64 / S66
页数:3
相关论文
共 18 条
[1]  
Adcock DM, 2004, ARCH PATHOL LAB MED, V128, P1360
[2]   Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications [J].
Aithal, GP ;
Day, CP ;
Kesteven, PJL ;
Daly, AK .
LANCET, 1999, 353 (9154) :717-719
[3]   Patient-Specific Decision-Making for Warfarin Therapy in Nonvalvular Atrial Fibrillation How Will Screening With Genetics and Imaging Help? [J].
Eckman, Mark H. ;
Wong, Lawrence K. S. ;
Soo, Yannie O. Y. ;
Lam, Wynnie ;
Yang, Song Ran ;
Greenberg, Steven M. ;
Rosand, Jonathan .
STROKE, 2008, 39 (12) :3308-3315
[4]   Death and disability from warfarin-associated intracranial and extracranial hemorrhages [J].
Fang, Margaret C. ;
Go, Alan S. ;
Chang, Yuchiao ;
Hylek, Elaine M. ;
Henault, Lori E. ;
Jensvold, Nancy G. ;
Singer, Daniel E. .
AMERICAN JOURNAL OF MEDICINE, 2007, 120 (08) :700-705
[5]   Age and the risk of warfarin-associated hemorrhage: The anticoagulation and risk factors in atrial fibrillation study [J].
Fang, Margaret C. ;
Go, Alan S. ;
Hylek, Elaine M. ;
Chang, Yuchiao ;
Henault, Lori E. ;
Jensvold, Nancy G. ;
Singer, Daniel E. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2006, 54 (08) :1231-1236
[6]   Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation [J].
Fang, MC ;
Chang, YC ;
Hylek, EM ;
Rosand, J ;
Greenberg, SM ;
Go, AS ;
Singer, DE .
ANNALS OF INTERNAL MEDICINE, 2004, 141 (10) :745-752
[7]   Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy [J].
Higashi, MK ;
Veenstra, DL ;
Kondo, LML ;
Wittkowsky, AK ;
Srinouanprachanh, SL ;
Farin, FM ;
Rettie, AE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (13) :1690-1698
[8]   Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin [J].
Limdi, Na ;
McGwin, G. ;
Goldstein, J. A. ;
Beasley, T. M. ;
Arnett, D. K. ;
Adler, B. K. ;
Baird, M. F. ;
Acton, R. T. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 (02) :312-321
[9]  
Margaglione M, 2000, THROMB HAEMOSTASIS, V84, P775
[10]   The effect of warfarin and intensity of anticoagulation on outcome of intracerebral Hemorrhage [J].
Rosand, J ;
Eckman, MH ;
Knudsen, KA ;
Singer, DE ;
Greenberg, SM .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (08) :880-884