Multiple sclerosis: The resolving lesion revealed

被引:22
作者
Raine, Cedric S. [1 ,2 ,3 ]
机构
[1] Albert Einstein Coll Med, Dept Pathol Neuropathol, Bronx, NY USA
[2] Albert Einstein Coll Med, Dept Neurol, Bronx, NY USA
[3] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY USA
关键词
Multiple sclerosis; Microglia; Foamy macrophages; Remyelination; Resolving plaque; Alternative activation; Regulatory mechanisms; PATHOLOGY; CELLS;
D O I
10.1016/j.jneuroim.2016.05.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A little studied lesion, the resolving lesion, is described in multiple sclerosis (MS). Unusual features of early resolving lesions comprised a fibrous astrogliotic parenchyma replete with lipid-laden (foamy) microglia/macrophages widely scattered throughout and lined up at the edge, separating demyelinated plaque from myelinated white matter. Ongoing myelin breakdown was absent, as was remyelination. Later resolving lesions displayed the unusual coexistence of macrophages and remyelination within the gliotic parenchyma. Collectively, these observations may provide for the first time evidence for a role in MS for mitigating factors like alternatively-activated (M2) microglia/macrophages, known to have an anti-inflammatory phenotype and to be associated with wound-healing and repair. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:2 / 6
页数:5
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