Three-Dimensional Biodegradable Structures Fabricated by Two-Photon Polymerization

被引：128

作者：

Claeyssens, Frederik ^{[1
]}

Hasan, Erol A. ^{[2
]}

Gaidukeviciute, Arune ^{[3
]}

Achilleos, Demetra S. ^{[3
,4
]}

Ranella, Anthi ^{[3
]}

Reinhardt, Carsten ^{[3
,6
]}

Ovsianikov, Aleksandr ^{[6
]}

Xiao Shizhou ^{[6
]}

Fotakis, Costas ^{[3
,5
]}

Vamvakaki, Maria ^{[3
,4
]}

Chichkov, Boris N. ^{[3
,6
]}

Farsari, Maria ^{[3
]}

机构：

[1] Univ Sheffield, Kroto Res Inst, Dept Mat Engn, Biomat & Tissue Engn Grp, Sheffield S3 7HQ, S Yorkshire, England

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] FORTH, IESL, Iraklion, Crete, Greece

[4] Univ Crete, Dept Mat Sci & Technol, Iraklion, Greece

[5] Univ Crete, Dept Phys, Iraklion, Greece

[6] Laser Zentrum Hannover eV, Hannover, Germany

来源：

LANGMUIR | 2009年 / 25卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

IN-VIVO DEGRADATION; SCAFFOLDS; COPOLYMERS; VITRO; BIOMATERIALS; BIOCOMPOSITE;

D O I：

10.1021/la803803m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two-photon polymerization has been employed to fabricate three-dimensional structures using the biodegradable triblock copolymer poly(epsilon-caprolactone-co-trimethylenecarbonate)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-trimethylenecarbonate) with 4,4'-bis(diethylamino)benzophenone as the photoinitiator. The fabricated structures were of good quality and had four micron resolution. Initial cytotoxicity tests show that the material does not affect cell proliferation. These studies demonstrate the potential of two-photon polymerization as a technology for the fabrication of biodegradable scaffolds for tissue engineering.

引用

页码：3219 / 3223

页数：5

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