Circular-shaped microfluidic device to study the effect of shear stress on cellular orientation

被引：6
作者：
Park, Da Yeon [1 ]
Kim, Tae Hyeon [2 ]
Lee, Jong Min [2 ]
Ahrberg, Christian D. [3 ]
Chung, Bong Geun [2 ]
机构：
[1] Sogang Univ, Dept Biomed Engn, Seoul, South Korea
[2] Sogang Univ, Dept Mech Engn, 35 Baekbeom Ro, Seoul 121742, South Korea
[3] Sogang Univ, Res Ctr, Seoul, South Korea
来源：
ELECTROPHORESIS | 2018年 / 39卷 / 14期
基金：
新加坡国家研究基金会;
关键词：
Cellular orientation; Circular-shaped microfluidic device; Shear stress; ENDOTHELIAL-CELLS; BLOOD-VESSELS; SMOOTH-MUSCLE; FLOW; SYSTEM; CHAMBERS; CANCER;
D O I：
10.1002/elps.201800109
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding the effects of shear stress on mammalian cells is a crucial factor for understanding a number of biological processes and diseases. Here, we show the development of a circular-shaped microfluidic device for the facile generation of shear stress gradients. With this microfluidic device, the effect of shear stress on orientation of human umbilical vein endothelial cells was studied. This microfluidic device, which enables to control the alignment of human umbilical vein endothelial cells within a microchannel, can be a valuable tool to mimic blood vessels.
引用
收藏
页码：1816 / 1820
页数：5
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