Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes

被引：301
作者：
Cao, Zehui [2 ]
Tong, Rong [1 ]
Mishra, Abhijit [1 ]
Xu, Weichen [2 ]
Wong, Gerard C. L. [1 ]
Cheng, Jianjun [1 ]
Lu, Yi [1 ,2 ]
机构：
[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 35期
基金：
美国国家科学基金会;
关键词：
aptamers; cisplatin; drug delivery; liposomes; SYSTEMATIC EVOLUTION; CANCER-CELLS; MACROMOLECULAR THERAPEUTICS; ANTIPROLIFERATIVE ACTIVITY; ANTI-HER2; IMMUNOLIPOSOMES; MOLECULAR RECOGNITION; RNA APTAMERS; TUMOR-CELLS; CISPLATIN; GROWTH;
D O I：
10.1002/anie.200901452
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolinaptamer- conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.
引用
收藏
页码：6494 / 6498
页数：5
相关论文
共 56 条
  • [1] Quantum dot - Aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer
    Bagalkot, Vaishali
    Zhang, Liangfang
    Levy-Nissenbaum, Etgar
    Jon, Sangyong
    Kantoff, Philip W.
    Langer, Robert
    Farokhzad, Omid C.
    [J]. NANO LETTERS, 2007, 7 (10) : 3065 - 3070
  • [2] Antiproliferative activity of G-rich oligonucleotides correlates with protein binding
    Bates, PJ
    Kahlon, JB
    Thomas, SD
    Trent, JO
    Miller, DM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) : 26369 - 26377
  • [3] Light-activated destruction of cancer cell nuclei by platinum diazide complexes
    Bednarski, PJ
    Grünert, R
    Zielzki, M
    Wellner, A
    Mackay, FS
    Sadler, PJ
    [J]. CHEMISTRY & BIOLOGY, 2006, 13 (01): : 61 - 67
  • [4] Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels - Selective targeting of endothelial regulatory protein pigpen
    Blank, M
    Weinschenk, T
    Priemer, M
    Schluesener, H
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) : 16464 - 16468
  • [5] Synergistic and antagonistic combinations of drugs in human prostate cancer cell lines in vitro
    Budman, DR
    Calabro, A
    Kreis, W
    [J]. ANTI-CANCER DRUGS, 2002, 13 (10) : 1011 - 1016
  • [6] RETRACTED: Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase (Retracted Article)
    Cerchia, L
    Ducongé, F
    Pestourie, C
    Boulay, J
    Aissouni, Y
    Gombert, K
    Tavitian, B
    de Franciscis, V
    Libri, D
    [J]. PLOS BIOLOGY, 2005, 3 (04) : 697 - 704
  • [7] Molecular recognition of small-cell lung cancer cells using aptamers
    Chen, Hui William
    Medley, Colin D.
    Sefah, Kwame
    Shangguan, Dihua
    Tang, Zhiwen
    Meng, Ling
    Smith, Josh E.
    Tan, Weihong
    [J]. CHEMMEDCHEM, 2008, 3 (06) : 991 - 1001
  • [8] Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    Cheng, Jianjun
    Teply, Benjamin A.
    Sherifi, Ines
    Sung, Josephine
    Luther, Gaurav
    Gu, Frank X.
    Levy-Nissenbaum, Etgar
    Radovic-Moreno, Aleksandar F.
    Langer, Robert
    Farokhzad, Omid C.
    [J]. BIOMATERIALS, 2007, 28 (05) : 869 - 876
  • [9] A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment
    Daniels, DA
    Chen, H
    Hicke, BJ
    Swiderek, KM
    Gold, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) : 15416 - 15421
  • [10] Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications
    Dapic, V
    Bates, PJ
    Trent, JO
    Rodger, A
    Thomas, SD
    Miller, DM
    [J]. BIOCHEMISTRY, 2002, 41 (11) : 3676 - 3685
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