Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

被引：15

作者：

Kamal, A ^{[1
]}

Srinivas, O ^{[1
]}

Ramulu, P ^{[1
]}

Ramesh, G ^{[1
]}

Kumar, PP ^{[1
]}

Kumar, MS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 16期

关键词：

pyrrolobenzodiazepine dimers; DNA binding affinity; cytotoxicity;

D O I：

10.1016/j.bmc.2004.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4337 / 4350

页数：14

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