Synthesis and antifungal activity of a ferrocene-fluconazole analogue

被引：118

作者：

Biot, C

François, N

Maciejewski, L

Brocard, J

Poulain, D

机构：

[1] Univ Sci & Technol, Ecole Natl Super Chim, UPRESA CNRS 8010, Grp Synth Organomet,Lab Catalyse, F-59652 Villeneuve Dascq, France

[2] Fac Med Lille, Lab Parasitol Mycol, F-59045 Lille, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00120-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel ferrocene-fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：839 / 841

页数：3

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