Differential pulse polarographic determination of tenoxicam in pharmaceuticals and added to blood

A new, simple and sensitive pulse polarographic method was developed for the determination of Tenoxicam. The analysis was performed in phosphate buffer, pH 5.3. Peak currents were measured with a static mercury drop electrode at -1.33V versus Ag/AgCl. The linear calibration range was 0.025-20 mu g ml(-1). The relative standard deviation at 0.8 mu g ml(-1) 1.5% (n = 10). The method was applied to two different commercial pharmaceutical preparations, containing ca. 20 mg drug per capsule, the relative standard deviations were found to be 2.20% and 2.23% (n = 10). The data were compared with the spectrophotometric method given in the literature. No difference was found. It was also shown that the method was applicable to tenoxicam added to plasma and whole blood. Mean recoveries were 99.5 +/- 0.5% and 99.1 +/- 0.4%, respectively, (n = 6). (C) 2000 Elsevier Science B.V. All rights reserved.