Tumor necrosis factor- induces prostate cancer cell migration in lymphatic metastasis through CCR7 upregulation

被引：79

作者：

Maolake, Aerken ^{[1
,2
]}

Izumi, Kouji ^{[1
]}

Natsagdorj, Ariunbold ^{[1
]}

Iwamoto, Hiroaki ^{[1
]}

Kadomoto, Suguru ^{[1
]}

Makino, Tomoyuki ^{[1
]}

Naito, Renato ^{[1
]}

Shigehara, Kazuyoshi ^{[1
]}

Kadono, Yoshifumi ^{[1
]}

Hiratsuka, Kaoru ^{[1
]}

Wufuer, Guzailinuer ^{[3
]}

Nastiuk, Kent L. ^{[2
]}

Mizokami, Atsushi ^{[1
]}

机构：

[1] Kanazawa Univ, Dept Integrat Canc Therapy & Urol, Grad Sch Med Sci, Kanazawa, Ishikawa, Japan

[2] Roswell Pk Canc Inst, Dept Canc Genet & Urol, Buffalo, NY 14263 USA

[3] Peoples Hosp Xinjiang Uyghur Autonomous Reg, Dept Hematol, Xinjiang, Peoples R China

来源：

CANCER SCIENCE | 2018年 / 109卷 / 05期

基金：

日本学术振兴会;

关键词：

C-C chemokine receptor type 7; lymph node; metastasis; prostate cancer; tumor necrosis factor-; BREAST-CANCER; TNF-ALPHA; GALLBLADDER CANCER; RECEPTOR; CLASSIFICATION; EXPRESSION; SURVIVAL; ANTIGEN;

D O I：

10.1111/cas.13586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Understanding the mechanism of lymph node metastasis, a poor prognostic sign for prostate cancer, and the further dissemination of the disease is important to develop novel treatment strategies. Recent studies have reported that C-C chemokine receptor 7 (CCR7), whose ligand is CCL21, is abundantly expressed in lymph node metastasis and promotes cancer progression. Tumor necrosis factor- (TNF-) is chronically produced at low levels within the tumor microenvironment. The aim of this study was to determine whether TNF- promotes prostate cancer dissemination from metastatic lymph nodes through activation of the CCL21/CCR7 axis. First, human prostate cancer cells were determined to express both TNF- and CCR7. Second, low concentrations of TNF- were confirmed to induce CCR7 in prostate cancer cells through phosphorylation of ERK. Finally, CCL21 was found to promote the migration of prostate cancer cells through phosphorylation of the protein kinase p38. Our results suggest that TNF- leads to the induction of CCR7 expression and that the CCL21/CCR7 axis might increase the metastatic potential of prostate cancer cells in lymph node metastasis.

引用

页码：1524 / 1531

页数：8

共 23 条

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