Do estrogens impact adolescent idiopathic scoliosis?

被引：48

作者：

Leboeuf, Dominique ^{[2
]}

Letellier, Kareen ^{[2
]}

Alos, Nathalie ^{[1
,2
]}

Edery, Patrick ^{[3
,4
]}

Moldovan, Florina ^{[1
,5
]}

机构：

[1] CHU St Justine, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, Fac Med, Montreal, PQ H3T 1C5, Canada

[3] Univ Lyon 1, F-69622 Lyon, France

[4] Hosp Civils Lyon, Serv Cytogenet Constitut, Grp Hosp Est, Ctr Biol & Pathol Est, F-69677 Bron, France

[5] Univ Montreal, Fac Med Dent, Montreal, PQ H3T 1C5, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 04期

基金：

加拿大健康研究院;

关键词：

MELATONIN SIGNALING DYSFUNCTION; RECEPTOR GENE POLYMORPHISMS; BONE-MINERAL DENSITY; BREAST-CANCER CELLS; GROWTH-PLATE; PERSISTENT OSTEOPENIA; CURVE PROGRESSION; PHYSICAL-ACTIVITY; ALPHA; ASSOCIATION;

D O I：

10.1016/j.tem.2008.12.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent discoveries in the pathogenesis of adolescent idiopathic scoliosis (AIS) indicate that various hormones, especially estrogens, have a role in its onset and development. This role for estrogen seems possible because of its interaction with factors that influence the development and progression of this spinal deformity. Additionally, estrogens impact bone remodeling and growth, as well as bone acquisition, all of which are affected in AIS. Despite the fact that estrogens are not causative factors of AIS, they could impact the progression of spinal deformity by interacting with factors that modulate bone growth, biomechanics and structure. Thus, clarifying the role of estrogens is essential for understanding how AIS evolves during skeletal growth and for the development of new therapeutic interventions.

引用

页码：147 / 152

页数：6

共 77 条

[1] Ultrastructural localization and distribution of proteoglycan in normal and scoliotic lumbar disc [J].