Identification and development of nanoscintillators for biotechnology applications

被引：28

作者：

Jung, J. Y. ^{[1
]}

Hirata, G. A. ^{[2
]}

Gundiah, G. ^{[5
]}

Derenzo, S. ^{[5
]}

Wrasidlo, W. ^{[3
,4
]}

Kesari, S. ^{[3
,4
]}

Makale, M. T. ^{[3
,4
]}

McKittrick, J. ^{[1
,6
]}

机构：

[1] Univ Calif San Diego, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[2] UNAM, Ctr Nanociencias & Nanotecnol, Ensenada 22860, Baja California, Mexico

[3] Univ Calif San Diego, Translat Neurooncol Labs, San Diego Moores Canc Ctr, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Neurosci, San Diego Moores Canc Ctr, La Jolla, CA 92093 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

[6] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA

来源：

JOURNAL OF LUMINESCENCE | 2014年 / 154卷

关键词：

Nanoscintillators; Drug delivery; Biomedical application; UV-emitting; SCINTILLATION PROPERTIES; PHOTOLUMINESCENCE PROPERTIES; BARIUM FLUORIDE; PARTICLE-SIZE; INORGANIC SCINTILLATORS; RADIATION; CE; LUMINESCENCE; NANOCRYSTALLINE; NANOPARTICLES;

D O I：

10.1016/j.jlumin.2014.05.040

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The purpose of this work is to investigate the radioluminescence emission properties in the range 300-400 nm of 15 nanoscintillators for potential application in radiation-triggered photodynamic therapy, and compare to those reported for single crystals with same composition. Garnet structures, silicates and an oxide activated with Pr3+ or Ce3+ were prepared by combustion synthesis and subsequently annealed at 1200 degrees C The (Y1-xPrx)(3)Al5O12 (x=0.0075, 0.01, 0.0125, 0.015, 0.0175) compositions have the highest luminosity, showing concentration behavior for x > 0.01. The average particle size of (Y0.99Pr0.01)(3)Al5O12 is 80 nm, which was obtained by post-annealing high power ultrasonic processing. These results demonstrate that Y1-xPrx)(3)Al5O12 is an excellent candidate for nanoscintillators-based biomedical applications. Comparisons to single crystal data indicate a general trend cannot be established between the radioluminescence emission intensity of nanoscintillators and single crystals with the same composition. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：569 / 577

页数：9

共 73 条

[41] APPLICABILITY OF BARIUM FLUORIDE AND CADMIUM TUNGSTATE SCINTILLATORS FOR WELL LOGGING [J].

MELCHER, CL ;

MANENTE, RA ;

SCHWEITZER, JS .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1989, 36 (01) :1188-1192

[42] Nanoscintillator Conjugates as Photodynamic Therapy-Based Radiosensitizers: Calculation of Required Physical Parameters [J].

Morgan, Nicole Y. ;

Kramer-Marek, Gabriela ;

Smith, Paul D. ;

Camphausen, Kevin ;

Capala, Jacek .

RADIATION RESEARCH, 2009, 171 (02) :236-244

[43]

Moses W.W., SCINTILLATOR REQUIRE

[44] Effects of Tb doping on the photoluminescence of Y2O3:Tb nanophosphors [J].

Muenchausen, R. E. ;

Jacobsohn, L. G. ;

Bennett, B. L. ;

McKigney, E. A. ;

Smith, J. F. ;

Valdez, J. A. ;

Cooke, D. W. .

JOURNAL OF LUMINESCENCE, 2007, 126 (02) :838-842

[45] Science and application of oxyorthosilicate nanophosphors [J].

Muenchausen, Ross E. ;

McKigney, Edward A. ;

Jacobsohn, Luiz G. ;

Blair, Michael W. ;

Bennett, Bryan L. ;

Cooke, D. Wayne .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2008, 55 (03) :1532-1535

[46] Untitled [J].

Murphy, Eric J. .

LIPIDS, 2008, 43 (02) :105-106

[47] Luminescence and scintillation mechanism in Ce3+ and Pr3+ doped (Lu, Y, Gd)3(Ga, Al)5O12 single crystal scintillators [J].

Nikl, M. ;

Kamada, K. ;

Kurosawa, S. ;

Yokota, Y. ;

Yoshikawa, A. ;

Pejchal, J. ;

Babin, V. .

PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 10, NO 2, 2013, 10 (02) :172-175

[48] Growth and scintillation properties of Pr-doped Lu3Al5O12 crystals [J].

Ogino, H ;

Yoshikawa, A ;

Nikl, M ;

Krasnikov, A ;

Kamada, K ;

Fukuda, T .

JOURNAL OF CRYSTAL GROWTH, 2006, 287 (02) :335-338

[49] New nanoplatform based on Gd2O2S:Eu3+ core: synthesis, characterization and use for in vitro bio-labelling [J].

Osseni, Semiyou. A. ;

Lechevallier, Severine ;

Verelst, Marc ;

Dujardin, Christophe ;

Dexpert-Ghys, Jeannette ;

Neumeyer, David ;

Leclercq, Marie ;

Baaziz, Houda ;

Cussac, Daniel ;

Santran, Veronique ;

Mauricot, Robert .

JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (45) :18365-18372

[50] Photo- and radioluminescence characteristics of bismuth germanate nanoparticles by sol-gel and pressure-assisted combustion synthesis [J].

Oviedo, M. J. ;

Contreras, O. ;

Rodriguez, C. E. ;

Macedo, Z. S. ;

Hirata, G. A. ;

McKittrick, J. .

OPTICAL MATERIALS, 2012, 34 (07) :1116-1119

← 1 2 3 4 5 6 7 8 →