Identification and development of nanoscintillators for biotechnology applications

被引：28

作者：

Jung, J. Y. ^{[1
]}

Hirata, G. A. ^{[2
]}

Gundiah, G. ^{[5
]}

Derenzo, S. ^{[5
]}

Wrasidlo, W. ^{[3
,4
]}

Kesari, S. ^{[3
,4
]}

Makale, M. T. ^{[3
,4
]}

McKittrick, J. ^{[1
,6
]}

机构：

[1] Univ Calif San Diego, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[2] UNAM, Ctr Nanociencias & Nanotecnol, Ensenada 22860, Baja California, Mexico

[3] Univ Calif San Diego, Translat Neurooncol Labs, San Diego Moores Canc Ctr, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Neurosci, San Diego Moores Canc Ctr, La Jolla, CA 92093 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

[6] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA

来源：

JOURNAL OF LUMINESCENCE | 2014年 / 154卷

关键词：

Nanoscintillators; Drug delivery; Biomedical application; UV-emitting; SCINTILLATION PROPERTIES; PHOTOLUMINESCENCE PROPERTIES; BARIUM FLUORIDE; PARTICLE-SIZE; INORGANIC SCINTILLATORS; RADIATION; CE; LUMINESCENCE; NANOCRYSTALLINE; NANOPARTICLES;

D O I：

10.1016/j.jlumin.2014.05.040

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The purpose of this work is to investigate the radioluminescence emission properties in the range 300-400 nm of 15 nanoscintillators for potential application in radiation-triggered photodynamic therapy, and compare to those reported for single crystals with same composition. Garnet structures, silicates and an oxide activated with Pr3+ or Ce3+ were prepared by combustion synthesis and subsequently annealed at 1200 degrees C The (Y1-xPrx)(3)Al5O12 (x=0.0075, 0.01, 0.0125, 0.015, 0.0175) compositions have the highest luminosity, showing concentration behavior for x > 0.01. The average particle size of (Y0.99Pr0.01)(3)Al5O12 is 80 nm, which was obtained by post-annealing high power ultrasonic processing. These results demonstrate that Y1-xPrx)(3)Al5O12 is an excellent candidate for nanoscintillators-based biomedical applications. Comparisons to single crystal data indicate a general trend cannot be established between the radioluminescence emission intensity of nanoscintillators and single crystals with the same composition. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：569 / 577

页数：9

共 73 条

[21] Ceramic scintillators [J].

Greskovich, C ;

Duclos, S .

ANNUAL REVIEW OF MATERIALS SCIENCE, 1997, 27 :69-88

[22] Luminescence enhancement of Y2O3:Eu3+ and Y2SiO5:Ce3+,Tb3+ core particles with SiO2 shells [J].

Han, J. K. ;

Hirata, G. A. ;

Talbot, J. B. ;

McKittrick, J. .

MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS, 2011, 176 (05) :436-441

[23]

Hernandez-Sanchez B.A., 2012, P SOC PHOTO-OPT INS, V8509

[24] SINGLE-CRYSTALS FOR RADIATION DETECTORS [J].

ISHII, M ;

KOBAYASHI, M .

PROGRESS IN CRYSTAL GROWTH AND CHARACTERIZATION OF MATERIALS, 1991, 23 :245-311

[25] Luminescence Temperature Quenching for Ce3+ and Pr3+ d-f Emission in YAG and LuAG [J].

Ivanovskikh, K. V. ;

Ogieglo, J. M. ;

Zych, A. ;

Ronda, C. R. ;

Meijerink, A. .

ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY, 2013, 2 (02) :R3148-R3152

[26] An investigation of X-ray luminosity versus crystalline powder granularity [J].

Janecek, Martin ;

Borade, Ramesh ;

Bourret-Courchesne, Edith ;

Derenzo, Stephen E. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2011, 659 (01) :252-257

[27] Growth and scintillation properties of Pr doped Gd3(Ga,Al)5O12 single crystals [J].

Kamada, Kei ;

Yanagida, Takayuki ;

Pejchal, Jan ;

Nikl, Martin ;

Endo, Takanori ;

Tsutumi, Kousuke ;

Usuki, Yoshiyuki ;

Fujimoto, Yutaka ;

Fukabori, Akihiro ;

Yoshikawa, Akira .

JOURNAL OF CRYSTAL GROWTH, 2012, 352 (01) :84-87

[28] Advantages and problems of nanocrystalline scintillators [J].

Klassen, N. V. ;

Kedrov, V. V. ;

Kurlov, V. N. ;

Ossipyan, Yu A. ;

Shmurak, S. Z. ;

Shmyt'ko, I. M. ;

Strukova, G. K. ;

Kobelev, N. P. ;

Kudrenko, E. A. ;

Krivko, O. A. ;

Kiselev, A. P. ;

Bazhenov, A. V. ;

Fursova, T. N. .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2008, 55 (03) :1536-1541

[29] Nanoscintillators for Microscopic Diagnostics of Biological and Medical Objects and Medical Therapy [J].

Klassen, Nikolay V. ;

Kedrov, Victor V. ;

Ossipyan, Yuri A. ;

Shmurak, Semen Z. ;

Shmyt'ko, Ivan M. ;

Krivko, Oksana A. ;

Kudrenko, Elena A. ;

Kurlov, Vladimir N. ;

Kobelev, Nikolay P. ;

Kiselev, Aleksander P. ;

Bozhko, Sergei I. .

IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2009, 8 (01) :20-32

[30]

KLASSEN NV, 2005, P 8 INT C IN SCINT T, P228

← 1 2 3 4 5 6 7 8 →