Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C-F bond activation

被引：40

作者：

Xu, Lei ^{[1
]}

Zhang, Qi ^{[2
]}

Xie, Qiang ^{[3
]}

Huang, Bei ^{[1
]}

Dai, Jian-Jun ^{[1
]}

Xu, Jun ^{[1
]}

Xu, Hua-Jian ^{[1
]}

机构：

[1] Hefei Univ Technol, Key Lab Adv Funct Mat & Devices Anhui Prov, Sch Biol & Med Engn, Hefei 230009, Anhui, Peoples R China

[2] Hefei Univ Technol, Inst Ind & Equipment Technol, Hefei 230009, Anhui, Peoples R China

[3] USTC, Affiliated Hosp 1, PET CT Ctr, Hefei 230001, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 35期

关键词：

FLUORINATED BUILDING-BLOCKS; CROSS-COUPLING REACTION; GEM-DIFLUOROALKENES; GRIGNARD-REAGENTS; STEREOSELECTIVE-SYNTHESIS; CARBONYL-COMPOUNDS; CONCISE SYNTHESIS; C(SP(3))-F BONDS; LEWIS-ACID; HYDRODEFLUORINATION;

D O I：

10.1039/c8cc01568f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive beta-F elimination and C-F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of alpha-trifluoromethyl ketones as building blocks by C-F bond activation.

引用

页码：4406 / 4409

页数：4

共 59 条

[1] Functionalization of Fluorinated Molecules by Transition-Metal-Mediated C-F Bond Activation To Access Fluorinated Building Blocks [J].