Synthesis of 6,7-dihydro-5H-dibenzo[c,e]azepines and biaryls by palladium-catalyzed Ullmann reaction

被引：15

作者：

Yu, Ming ^{[1
]}

Tang, Ri-Yuan ^{[1
]}

Li, Jin-Heng ^{[1
,2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Sci, Wenzhou 325035, Peoples R China

[2] Hunan Normal Univ, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China

来源：

TETRAHEDRON | 2009年 / 65卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Palladium; The Ullmann reaction; 6,7-Dihydro-5H-dibenzo[c,e]azepine; Biaryls; INTRAMOLECULAR COUPLING REACTIONS; ARYL HALIDES; VINYL HALIDES; AMBIENT-TEMPERATURE; ZEROVALENT NICKEL; BOND FORMATION; WATER; ZINC; CONVENIENT; OXAZOLINES;

D O I：

10.1016/j.tet.2009.02.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel palladium-catalyzed Ullmann protocol is described for the synthesis of 6,7-dihydro-5H-dibenzo[c,e]azepines and biaryls. In the presence of Pd(OAc)(2) and KOAc, intramolecular or intermolecular Ullmann coupling of aryl halides proceeds efficiently under ligand-free and aerobic conditions to afford the corresponding 6,7-dihydro-5H-dibenzo[c,e]azepines and biaryls in moderate to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3409 / 3416

页数：8

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