Tau gene polymorphisms and apolipoprotein E ε4 may interact to increase risk for Alzheimer's disease

被引：51

作者：

Lilius, L

Fabre, SF

Basun, H

Forsell, C

Axelman, K

Mattila, K

Andreadis, A

Viitanen, M

Winblad, B

Fratiglioni, L

Lannfelt, L ^{[1
]}

机构：

[1] Novum, Karolinska Inst, Div Geriatr Med, KFC,NEUROTEC, S-14186 Huddinge, Sweden

[2] Eunice Kennedy Shriver Ctr Mental Retardat Inc, Dept Biomed Sci, Waltham, MA 02154 USA

[3] Stockholm Gerontol Res Ctr, S-11382 Stockholm, Sweden

来源：

NEUROSCIENCE LETTERS | 1999年 / 277卷 / 01期

关键词：

Alzheimer's disease; tau; gene; polymorphism; apolipoprotein E;

D O I：

10.1016/S0304-3940(99)00833-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In an effort to analyze the genetic role of tau in Alzheimer's disease (AD), 17 polymorphisms were identified. Eleven of these polymorphisms were in complete linkage disequilibrium and segregated as two haplotypes, A and B. The A and B haplotypes were investigated in 269 AD cases and 238 controls from two different sources, a clinic-based group (mean age of onset 65 +/- 9 years), and a population-based group (mean age of onset 80 +/- 5 years). A synergistic effect between the common tau genotype AA and apolipoprotein E (APOE epsilon 4) was found in the clinic-based AD group. Our study suggests that the common tau genotype AA may interact with APQE epsilon 4 in increasing the risk of AD in a subgroup of the AD population. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：29 / 32

页数：4

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