Some results on D-optimal designs for nonlinear models with applications

被引：13
作者：
Li, Gang [1 ]
Majumdar, Dibyen [1 ,2 ]
机构：
[1] GlaxoSmithKline Inc, Med Dev Ctr, Collegeville, PA 19426 USA
[2] Univ Illinois, Dept Math Stat & Comp Sci, Chicago, IL 60607 USA
来源：
BIOMETRIKA | 2009年 / 96卷 / 02期
基金：
美国国家科学基金会;
关键词：
Compartmental model; General equivalence theorem; Minimally supported design; Poisson regression; Tchebycheff system; REGRESSION-MODELS;
D O I：
10.1093/biomet/asp004
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sufficient conditions are established for the locally D$-optimal design for a nonlinear model to have a minimal number of support points. The conditions are applied to obtain locally D-optimal designs for a one-compartment pharmacokinetic model and a Poisson regression model.
引用
收藏
页码：487 / 493
页数：7
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