CFTR Polymorphisms in Patients with Alcoholic Chronic Pancreatitis

被引：10
作者：
Gouvea da Costa, Marianges Zadrozny [1 ]
Guarita, Dulce Reis [1 ]
Ono-Nita, Suzane Kioko [1 ]
Nogueira, Jeronimo de Alencar [1 ]
Nita, Marcelo Eidi [1 ]
Paranagua-Vezozzo, Denise Cerqueira [1 ]
de Souza, Marcelo Tavares [1 ]
do Carmo, Eliane Pereira [1 ]
de Sa Teixeira, Ana Cristina [1 ]
Carrilho, Flair Jose [1 ]
机构：
[1] Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05403000 Sao Paulo, Brazil
来源：
PANCREATOLOGY | 2009年 / 9卷 / 1-2期
基金：
巴西圣保罗研究基金会;
关键词：
Pancreatitis/genetics; Cystic fibrosis transmembrane conductance regulator; Polymorphisms; Alcoholism; CYSTIC-FIBROSIS GENE; SERINE-PROTEASE INHIBITOR; JAPANESE MALE ALCOHOLICS; TYPE-1; SPINK1; GENE; MUTATION ANALYSIS; KAZAL TYPE-1; DISEASE; CANCER; ASSOCIATION; MANAGEMENT;
D O I：
10.1159/000178889
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Introduction: Pancreas susceptibility to alcohol is variable and only 5-10% of chronic alcohol abusers develop chronic pancreatitis; the role of genetic factors in this process is unknown. The CFTR gene encodes a protein that acts on epithelial cells and plays a key role in normal exocrine pancreatic function. Methods: This study investigated the frequency of polymorphisms in intron 8 of the CFTR gene in patients with alcoholic chronic pancreatitis. Three groups of patients were studied: group A-68 adult alcoholics with a diagnosis of chronic pancreatitis; group B-68 adult alcoholics without pancreatic disease or liver cirrhosis and group C-104 healthy nonalcoholic adults. Results: T5/T7 genotype was more frequent in group A (11.8%) than in group B (2.9%) (p = 0.0481), and there was no statistical difference when groups A and C (5.8%) were compared (p = 0.1317). The haplotype combination (TG) 10-T7/(TG) 11-T7 was more frequent in groups B (23.5%) and C (20.2%) than in group A (7.3%) (p = 0.0080 and 0.0162). Conclusion: There are differences when these three groups are compared and individuals with T5/T7 genotype might have a greater risk of developing chronic pancreatitis when they become chronic alcoholics. Copyright (C) 2008 S. Karger AG, Basel and IAP
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页码：173 / 181
页数：9
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