A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19

被引：30

作者：

Esam, Zohreh ^{[1
,2
]}

机构：

[1] Mazandaran Univ Med Sci, Dept Med Chem, Pharmaceut Sci Res Ctr, Sari, Iran

[2] Islamic Azad Univ, Fac Pharm, Dept Med Chem, Ayatollah Amoli Branch, Amol, Iran

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2020年 / 167卷

关键词：

Metformin; COVID-19; SARS-CoV-2; V-ATPase; eNHEs;

D O I：

10.1016/j.diabres.2020.108282

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：2

共 10 条

[1] The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the current evidence [J].

Chatterjee, Pranab ;

Nagi, Nazia ;

Agarwal, Anup ;

Das, Bhabatosh ;

Banerjee, Sayantan ;

Sarkar, Swarup ;

Gupta, Nivedita ;

Gangakhedkar, Raman R. .

INDIAN JOURNAL OF MEDICAL RESEARCH, 2020, 151 (2-3) :147-159

[2] Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis [J].

Chen, Jing-Yu ;

Qiao, Kun ;

Liu, Feng ;

Wu, Bo ;

Xu, Xin ;

Jiao, Guo-Qing ;

Lu, Rong-Guo ;

Li, Hui-Xing ;

Zhao, Jin ;

Huang, Jian ;

Yang, Yi ;

Lu, Xiao-Jie ;

Li, Jia-Shu ;

Jiang, Shu-Yun ;

Wang, Da-Peng ;

Hu, Chun-Xiao ;

Wang, Gui-Long ;

Huang, Dong-Xiao ;

Jiao, Guo-Hui ;

Wei, Dong ;

Ye, Shu-Gao ;

Huang, Jian-An ;

Zhou, Li ;

Zhang, Xiao-Qin ;

He, Jian-Xing .

CHINESE MEDICAL JOURNAL, 2020, 133 (12) :1390-1396

[3] Metformin and Aging: A Review [J].

Glossmann, Hartmut H. ;

Lutz, Oliver M. D. .

GERONTOLOGY, 2019, 65 (06) :581-590

[4] Regulation of Organelle Function by Metformin [J].

Kim, Jeongho ;

You, Young-Jai .

IUBMB LIFE, 2017, 69 (07) :459-469

[5] THE BASIS OF ANTIMALARIAL ACTION - NON-WEAK BASE EFFECTS OF CHLOROQUINE ON ACID VESICLE PH [J].

KROGSTAD, DJ ;

SCHLESINGER, PH .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1987, 36 (02) :213-220

[6]

LIU J, 2020, CELL DISCOV, V6, DOI DOI 10.1038/S41421-020-0156-0

[7] SARS-CoV-2 and COVID-19: What are our options? Where should we focus our attention on to find new drugs and strategies? [J].

Magro, Giuseppe .

TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2020, 37

[8] Metformin reverses established lung fibrosis in a bleomycin model [J].

Rangarajan, Sunad ;

Bone, Nathaniel B. ;

Zmijewskal, Anna A. ;

Jiang, Shaoning ;

Park, Dae Won ;

Bernard, Karen ;

Locy, Morgan L. ;

Ravi, Saranya ;

Deshane, Jessy ;

Mannon, Roslyn B. ;

Abraham, Edward ;

Darley-Usmar, Victor ;

Thannickal, Victor J. ;

Zmijewski, Jaroslaw W. .

NATURE MEDICINE, 2018, 24 (08) :1121-+

[9] Metformin in COVID-19: A possible role beyond diabetes [J].

Sharma, Swati ;

Ray, Avik ;

Sadasivam, Balakrishnan .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2020, 164

[10] Metformin Activates AMPK through the Lysosomal Pathway [J].

Zhang, Chen-Song ;

Li, Mengqi ;

Ma, Teng ;

Zong, Yue ;

Cui, Jiwen ;

Feng, Jin-Wei ;

Wu, Yu-Qing ;

Lin, Shu-Yong ;

Lin, Sheng-Cai .

CELL METABOLISM, 2016, 24 (04) :521-522

← 1 →