Conjugated polymer nanomaterials for theranostics

被引:77
作者
Qian, Cheng-gen [1 ,2 ,3 ,4 ]
Chen, Yu-lei [1 ,2 ]
Feng, Pei-jian [1 ,2 ]
Xiao, Xuan-zhong [1 ,2 ]
Dong, Mei [1 ,2 ]
Yu, Ji-cheng [3 ,4 ,5 ,6 ]
Hu, Quan-yin [3 ,4 ,5 ,6 ]
Shen, Qun-dong [1 ,2 ]
Gu, Zhen [3 ,4 ,5 ,6 ,7 ]
机构
[1] Nanjing Univ, Dept Polymer Sci & Engn, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ, Key Lab High Performance Polymer Mat & Technol MO, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China
[3] Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Raleigh, NC 27695 USA
[4] North Carolina State Univ, Raleigh, NC 27695 USA
[5] Univ North Carolina Chapel Hill, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA
[6] Univ North Carolina Chapel Hill, Div Pharmacoengn & Mol Pharmaceut, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA
[7] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA
基金
中国国家自然科学基金;
关键词
conjugated polymer; theranostics; biomedical imaging; photodynamic therapy; photothermal therapy; stimuli; responsive drug delivery; PHOSPHORESCENT IRIDIUM(III) COMPLEXES; IN-VIVO; DRUG-DELIVERY; PHOTOTHERMAL THERAPY; PHOTOACOUSTIC MICROSCOPY; PHOTODYNAMIC THERAPY; CANCER-THERAPY; SIRNA DELIVERY; IMAGING PROBES; QUANTUM DOTS;
D O I
10.1038/aps.2017.42
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrared (NIR) imaging, two-photon (TP) imaging, photoacoustic (PA) imaging, and multimodal (MM) imaging, are introduced. Then, CPN-based photodynamic therapy (PDT) and photothermal therapy (PTT) are surveyed. A variety of stimuli-responsive CPN systems for drug delivery are also summarized, and the promising trends and translational challenges are discussed.
引用
收藏
页码:764 / 781
页数:18
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