Branch-Selective Alkene Hydroarylation by Cooperative Destabilization: Iridium-Catalyzed ortho-Alkylation of Acetanilides

被引：82

作者：

Crisenza, Giacomo E. M. ^{[1
]}

Sokolova, Olga O. ^{[1
]}

Bower, John F. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 49期

基金：

英国工程与自然科学研究理事会;

关键词：

acetanilides; branch selectivity; hydroarylation; iridium; phosphine ligands; C-H ACTIVATION; REDUCTIVE ELIMINATION; COUPLING REACTIONS; BOND FORMATION; COMPLEXES; FUNCTIONALIZATION; ARYLATION; INDOLE; ALKENYLATION; STABILITY;

D O I：

10.1002/anie.201506581

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iridium(I) catalyst system, modified with the wide-bite-angle and electron-deficient bisphosphine d(F)ppb (1,4-bis(di(pentafluorophenyl)phosphino)butane) promotes highly branch-selective hydroarylation reactions between diverse acetanilides and aryl-or alkyl-substituted alkenes. This provides direct and ortho-selective access to synthetically challenging anilines, and addresses long-standing issues associated with related Friedel-Crafts alkylations.

引用

页码：14866 / 14870

页数：5

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