Is exercise a senolytic medicine? A systematic review

被引:47
作者
Chen, Xiang-Ke [1 ]
Yi, Zhen-Ni [2 ]
Wong, Gordon Tin-Chun [3 ]
Hasan, Kazi Md Mahmudul [2 ]
Kwan, Joseph Shiu-Kwong [4 ]
Ma, Alvin Chun-Hang [2 ]
Chang, Raymond Chuen-Chung [1 ,5 ]
机构
[1] Univ Hong Kong, LKS Fac Med, Sch Biomed Sci, Lab Neurodegenerat Dis, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong, Peoples R China
[3] Univ Hong Kong, LKS Fac Med, Dept Anaesthesiol, Hong Kong, Peoples R China
[4] Imperial Coll London, Dept Brain Sci, London W12 0NN, England
[5] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China
关键词
cellular senescence; exercise; senescent cells; senolytic medicine; senolytics; SENESCENT CELLS; CELLULAR SENESCENCE; PHYSICAL INACTIVITY; SKELETAL-MUSCLE; DNA-DAMAGE; EXPRESSION; CLEARANCE; APOPTOSIS; AUTOPHAGY; P16(INK4A);
D O I
10.1111/acel.13294
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years. Exercise is a potent anti-aging and anti-chronic disease medicine, which has shown the capacity to lower the markers of cellular senescence over the past decade. However, whether exercise is a senolytic medicine for aging and various diseases remains unclear. Here, we have conducted a systematic review of the published literature studying the senolytic effects of exercise or physical activity on senescent cells under various states in both human and animal models. Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not healthy animals. The discrepancy between human and animal studies may be due to the relatively small volume of research and the variations in markers of senescent cells, types of cells/tissues, and health conditions. These findings suggest that exercise has senolytic properties under certain conditions, which warrant further investigations.
引用
收藏
页数:12
相关论文
共 63 条
  • [1] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    Baker, Darren J.
    Wijshake, Tobias
    Tchkonia, Tamar
    LeBrasseur, Nathan K.
    Childs, Bennett G.
    van de Sluis, Bart
    Kirkland, James L.
    van Deursen, Jan M.
    [J]. NATURE, 2011, 479 (7372) : 232 - U112
  • [2] Aerobic Endurance Exercise Ameliorates Renal Vascular Sclerosis in Aged Mice by Regulating PI3K/AKT/mTOR Signaling Pathway
    Bao, Chuncha
    Yang, Zhong
    Li, Qian
    Cai, Qiyan
    Li, Hongli
    Shu, Bin
    [J]. DNA AND CELL BIOLOGY, 2020, 39 (02) : 310 - 320
  • [3] The signals and pathways activating cellular senescence
    Ben-Porath, I
    Weinberg, RA
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (05) : 961 - 976
  • [4] Blair SN, 2009, BRIT J SPORT MED, V43, P1
  • [5] Lack of Exercise Is a Major Cause of Chronic Diseases
    Booth, Frank W.
    Roberts, Christian K.
    Laye, Matthew J.
    [J]. COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) : 1143 - 1211
  • [6] Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
    Cai, Yusheng
    Zhou, Huanhuan
    Zhu, Yinhua
    Sun, Qi
    Ji, Yin
    Xue, Anqi
    Wang, Yuting
    Chen, Wenhan
    Yu, Xiaojie
    Wang, Longteng
    Chen, Han
    Li, Cheng
    Luo, Tuoping
    Deng, Hongkui
    [J]. CELL RESEARCH, 2020, 30 (07) : 574 - 589
  • [7] Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
    Chang, Jianhui
    Wang, Yingying
    Shao, Lijian
    Laberge, Remi-Martin
    Demaria, Marco
    Campisi, Judith
    Janakiraman, Krishnamurthy
    Sharpless, Norman E.
    Ding, Sheng
    Feng, Wei
    Luo, Yi
    Wang, Xiaoyan
    Aykin-Burns, Nukhet
    Krager, Kimberly
    Ponnappan, Usha
    Hauer-Jensen, Martin
    Meng, Aimin
    Zhou, Daohong
    [J]. NATURE MEDICINE, 2016, 22 (01) : 78 - +
  • [8] Senescent cells: a therapeutic target for cardiovascular disease
    Childs, Bennett G.
    Li, Hu
    van Deursen, Jan M.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (04) : 1217 - 1228
  • [9] Cellular senescence in aging and age-related disease: from mechanisms to therapy
    Childs, Bennett G.
    Durik, Matej
    Baker, Darren J.
    van Deursen, Jan M.
    [J]. NATURE MEDICINE, 2015, 21 (12) : 1424 - 1435
  • [10] Cellular senescence in cancer and aging
    Collado, Manuel
    Blasco, Maria A.
    Serrano, Manuel
    [J]. CELL, 2007, 130 (02) : 223 - 233