Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores

被引：26

作者：

Dituri, Francesco ^{[1
]}

Serio, Gabriella ^{[1
]}

Filannino, Doriana ^{[1
]}

Mascolo, Antonella ^{[1
]}

Sacco, Rodolfo ^{[2
]}

Villa, Erica ^{[3
]}

Giannelli, Gianluigi ^{[1
]}

机构：

[1] Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

[2] Univ Pisa, Cisanello Hosp, Dept Gastroenterol, I-56124 Pisa, Italy

[3] Univ Modena & Reggio Emilia, Dept Internal Med, I-41124 Modena, Italy

来源：

CANCER LETTERS | 2014年 / 353卷 / 02期

关键词：

Biomarkers; TGF-beta; E-cadherin; APP; MMP-2; PLASMA TRANSFORMING GROWTH-FACTOR-BETA-1; CELL LUNG-CANCER; ALPHA-FETOPROTEIN; GROWTH-FACTOR; E-CADHERIN; TGF-BETA; EXPRESSION; PROGNOSIS; LAMININ-5;

D O I：

10.1016/j.canlet.2014.07.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TGF-beta 1 was inversely correlated with E-cadherin but significantly correlated with VEGF. VEGF and AFP had a low coefficient value but statistically significant. A significant correlation was found between E-cadherin and MMP2. In conclusion, TGF-beta and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：264 / 271

页数：8

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