Marine natural products as antituberculosis agents

被引：156

作者：

El Sayed, KA ^{[1
]}

Bartyzel, P ^{[1
]}

Shen, XY ^{[1
]}

Perry, TL ^{[1
]}

Kjawiony, JK ^{[1
]}

Hamann, MT ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, NCNPR, University, MS 38677 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 07期

基金：

美国国家卫生研究院;

关键词：

antibiotics; natural products; marine metabolites; biologically active compounds;

D O I：

10.1016/S0040-4020(99)01093-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In an attempt to characterize additional structural classes that could serve as lead antituberculosis agents, 48 structurally diverse marine-derived natural and semisynthetic compounds were examined for in vitro activity against Mycobacterium tuberculosis. Three new classes of compounds including C-19 hydroxy steroids, scalarin sesquiterpenoids and tetrabromo spirocyclohexadienylisoxazolines have been identified as having potential as leads for continued investigations as new antituberculosis agents. New additions to the established antituberculosis structural classes quinone-methide and peptide are also reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：949 / 953

页数：5

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