Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study

被引：7

作者：

Tregellas, Jason R. ^{[1
,2
,3
]}

Smucny, Jason ^{[2
,3
]}

Legget, Kristina T. ^{[2
,3
]}

Stevens, Karen E. ^{[3
]}

机构：

[1] Denver VA Med Ctr, Res Serv, Denver, CO USA

[2] Univ Colorado, Neurosci Program, Aurora, CO 80045 USA

[3] Univ Colorado, Dept Psychiat, Aurora, CO 80045 USA

来源：

SCHIZOPHRENIA RESEARCH | 2015年 / 169卷 / 1-3期

关键词：

Gating; Ketogenic diet; Hippocampus; P50; Schizophrenia; NICOTINIC ACETYLCHOLINE-RECEPTORS; CEREBRAL-BLOOD-FLOW; NEUROPHYSIOLOGICAL EVIDENCE; HIPPOCAMPAL-FORMATION; SCHIZOPHRENIA; DYSFUNCTION; EPILEPSY; HYPERACTIVITY; INHIBITION; MECHANISMS;

D O I：

10.1016/j.schres.2015.09.022

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Although the ketogenic diet has shown promise in a pilot study and case report in schizophrenia, its effects in animal models of hypothesized disease mechanisms are unknown. This study examined effects of treatment with the ketogenic diet on hippocampal P20/N40 gating in DBA/2 mice, a translational endophenotype that mirrors inhibitory deficits in P50 sensory gating in schizophrenia patients. As expected, the diet increased blood ketone levels. Animals with the highest ketone levels showed the lowest P20/N40 gating ratios. These preliminary results suggest that the ketogenic diet may effectively target sensory gating deficits and is a promising area for additional research in schizophrenia. Published by Elsevier B.V.

引用

页码：351 / 354

页数：4

共 45 条

[1]

ADLER LE, 1982, BIOL PSYCHIAT, V17, P639

[2] Concurrent Functional Magnetic Resonance Imaging and Electroencephalography Assessment of Sensory Gating in Schizophrenia [J].

Bak, Nikolaj ;

Rostrup, Egill ;

Larsson, Henrik B. W. ;

Glenthoj, Birte Y. ;

Oranje, Bob .

HUMAN BRAIN MAPPING, 2014, 35 (08) :3578-3587

[3] AUDITORY SENSORY GATING IN HIPPOCAMPAL-NEURONS - A MODEL SYSTEM IN THE RAT [J].

BICKFORDWIMER, PC ;

NAGAMOTO, H ;

JOHNSON, R ;

ADLER, LE ;

EGAN, M ;

ROSE, GM ;

FREEDMAN, R .

BIOLOGICAL PSYCHIATRY, 1990, 27 (02) :183-192

[4] Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer's Pathology [J].

Brownlow, Milene L. ;

Benner, Leif ;

D'Agostino, Dominic ;

Gordon, Marcia N. ;

Morgan, Dave .

PLOS ONE, 2013, 8 (09)

[5] SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY WITH TC-99M-EXAMETAZIME IN UNMEDICATED SCHIZOPHRENIC-PATIENTS [J].

EBMEIER, KP ;

BLACKWOOD, DHR ;

MURRAY, C ;

SOUZA, V ;

WALKER, M ;

DOUGALL, N ;

MOFFOOT, APR ;

OCARROLL, RE ;

GOODWIN, GM .

BIOLOGICAL PSYCHIATRY, 1993, 33 (07) :487-495

[6]

FREEDMAN R, 1983, BIOL PSYCHIAT, V18, P537

[7] THE LEFT MEDIAL TEMPORAL REGION AND SCHIZOPHRENIA - A PET STUDY [J].

FRISTON, KJ ;

LIDDLE, PF ;

FRITH, CD ;

HIRSCH, SR ;

FRACKOWIAK, RSJ .

BRAIN, 1992, 115 :367-382

[8] Neuronal substrates of sensory gating within the human brain [J].

Grunwald, T ;

Boutros, NN ;

Pezer, N ;

von Oertzen, J ;

Fernández, G ;

Schaller, C ;

Elger, CE .

BIOLOGICAL PSYCHIATRY, 2003, 53 (06) :511-519

[9]

GUR RE, 1995, ARCH GEN PSYCHIAT, V52, P657

[10] Tropisetr in DBA/2 on improves deficient inhibitory auditory processing mice:: role of α7 nicotinic acetylcholine receptors [J].

Hashimoto, K ;

Iyo, M ;

Freedman, R ;

Stevens, KE .

PSYCHOPHARMACOLOGY, 2005, 183 (01) :13-19

← 1 2 3 4 5 →