The Oxidative Derivatization Method for the Spectrofluorimetric Determination of Periciazine in Pharmaceutical Preparations

被引：0

作者：

Blazheyevskiy, M. Ye ^{[1
]}

Scrypynets, Yu, V ^{[2
]}

Yegorova, A., V ^{[2
]}

Antonovich, V. P. ^{[2
]}

机构：

[1] Natl Univ Pharm, 53 Pushkinska Str, UA-61002 Kharkiv, Ukraine

[2] NAS Ukraine, Bogatsky Physicochem Inst, Lustdorfska Doroga 86, UA-65080 Odesa, Ukraine

来源：

METHODS AND OBJECTS OF CHEMICAL ANALYSIS | 2020年 / 15卷 / 01期

关键词：

spectrofluorimetry; Oxone; determination; periciazine; phenothiazine sulphoxide; pharmaceuticals; PLASMA;

D O I：

10.17721/moca.2020.21-26

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The oxidative derivatization method for the indirect spectrofluorimetric determination of Periciazine has been presented. Potassium hydrogenperoxymonosulfate (Oxone (R)) is proposed as a derivatizing agent for Periciazine, yielding the strongly fluorescent Periciazine sulfoxide. A highly sensitive, simple and rapid method for determination of the Periciazine by fluorescence of its oxidation product with Oxone (R) solution in 0.02 M hydrochloric acid solution (lambda(ex) = 364 nm; lambda(em)=444 nm) has been developed. The calibration plot is linear in concentration range of 0.05-4,00 mu g mL(-1), LOQ (10S) is 0.05 mu g mL(-1). The possibility of quantitative determination of Periciazine in pharmaceutical preparations (Neuleptil (R), 10 mg capsules and Neuleptil (R), a 30 mL 4% oral (solution) drops) has been shown RSD <2.2% (delta< RSD).

引用

页码：21 / 26

页数：6

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