Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Outcome of Immune Checkpoint Inhibitors

被引：36
|
作者：
Xie, Xianhe [1 ]
Liu, Junjin [1 ]
Yang, Haitao [1 ]
Chen, Huijuan [1 ]
Zhou, Sijing [1 ]
Lin, Heng [1 ]
Liao, Ziyuan [1 ]
Ding, Yin [1 ]
Ling, Liting [1 ]
Wang, Xuewen [1 ]
机构：
[1] Fujian Med Univ, Affiliated Hosp 1, Dept Chemotherapy, Chazhong Rd 20, Fuzhou 350005, Fujian, Peoples R China
来源：
CANCER INVESTIGATION | 2019年 / 37卷 / 06期
关键词：
Melanoma; non-small cell lung cancer (NSCLC); metastatic renal cell carcinoma (mRCC); immune checkpoint inhibitors (ICI); neutrophil-to-lymphocyte ratio (NLR); CELL LUNG-CANCER; NIVOLUMAB-TREATED PATIENTS; CLINICAL-RESPONSE; CTLA-4; BLOCKADE; PD-1; MARKER; IMMUNOTHERAPY; PROGRESSION; MECHANISMS; SURVIVAL;
D O I：
10.1080/07357907.2019.1639057
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR: 2.61, 95% confidence intervals (CI): 1.77-3.86, p < 0.00001) and PFS (HR: 1.74, 95% CI: 1.34-2.27, p < 0.0001). Stratified analyses on tumor types, ICI agents, the cutoff value of NLR and study regions exhibited the similar outcomes. This study demonstrated that elevated NLR was a predictor of poor OS and PFS for ICI.
引用
收藏
页码：265 / 274
页数：10
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