A tour through the transcriptional landscape of platelets

被引：95
作者：
Schubert, Sebastian [1 ]
Weyrich, Andrew S. [1 ,2 ]
Rowley, Jesse W. [1 ,2 ]
机构：
[1] Univ Utah Sch Med, Program Mol Med, Salt Lake City, UT 84112 USA
[2] Univ Utah Sch Med, Dept Internal Med, Salt Lake City, UT 84112 USA
来源：
BLOOD | 2014年 / 124卷 / 04期
基金：
美国国家卫生研究院;
关键词：
FACTOR PATHWAY INHIBITOR; GENOME-WIDE ASSOCIATION; 5' UNTRANSLATED REGION; MESSENGER-RNA DECAY; POSTTRANSCRIPTIONAL REGULATION; ACTIVATED PLATELETS; ENDOTHELIAL-CELLS; P-SELECTIN; TRANSLATIONAL CONTROL; ANUCLEATE PLATELETS;
D O I：
10.1182/blood-2014-04-512756
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The RNA code found within a platelet and alterations of that code continue to shed light onto the mechanistic underpinnings of platelet function and dysfunction. It is now known that features of messenger RNA (mRNA) in platelets mirror those of nucleated cells. This review serves as a tour guide for readers interested in developing a greater understanding of platelet mRNA. The tour provides an in-depth and interactive examination of platelet mRNA, especially in the context of next-generation RNA sequencing. At the end of the expedition, the reader will have a better grasp of the topography of platelet mRNA and how it impacts platelet function in health and disease.
引用
收藏
页码：493 / 502
页数：10
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