Copper-mediated intramolecular oxidative C-H/N-H cross-coupling of α-alkenoyl ketene N,S-acetals to synthesize pyrrolone derivatives

被引：35

作者：

Huang, Fei ^{[1
]}

Wu, Ping ^{[1
]}

Wang, Liandi ^{[1
]}

Chen, Jiping ^{[1
]}

Sun, Chenglin ^{[1
]}

Yu, Zhengkun ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 83期

基金：

中国国家自然科学基金;

关键词：

SUBSTITUTED PYRROLIN-4-ONES; HETEROCYCLES; CYCLIZATION; ACTIVATION; ACCESS; AMIDES; OXYGEN;

D O I：

10.1039/c4cc05837b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

CuCl2 and CuBr2-mediated intramolecular oxidative C-H/N-H cross-coupling/halogenation of beta-thioalkyl-substituted alpha-alkenoyl ketene N,S-acetals occurred efficiently, affording 4-halo-5-thioalkyl-3-pyrrolones. Tunable C-S and C-halo bond transformations of the resultant pyrrolone derivatives led to highly functionalized N-heterocyclic compounds.

引用

页码：12479 / 12481

页数：3

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