Bioactive Alkaloids from Endophytic Aspergillus fumigatus

被引：78

作者：

Ge, Hui Ming ^{[1
]}

Yu, Zhi Guo ^{[1
]}

Zhang, Jie ^{[1
]}

Wu, Jun Hua ^{[1
]}

Tan, Ren Xiang ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 04期

关键词：

CELL CYCLE INHIBITORS; A-C;

D O I：

10.1021/np800700e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 known compounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity against human leukemia cells (K562) with an IC50 value of 3.1 mu M, which was comparable to that of doxorubicin hydrochloride, a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 mu M concentration.

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页码：753 / 755

页数：3

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