Apigenin Exerts Anti-inflammatory Effects in an Experimental Model of Acute Pancreatitis by Down-regulating TNF-α

被引：42

作者：

Charalabopoulos, Alexandros ^{[1
,2
]}

Davakis, Spyridon ^{[1
,3
]}

Lambropoulou, Maria ^{[4
]}

Papalois, Apostolos ^{[2
]}

Simopoulos, Cons Tantinos ^{[5
]}

Tsaroucha, Alexandra ^{[5
]}

机构：

[1] Mid Essex Hosp Serv NHS Trust, Broomfield Hosp, Dept Upper Gastrointestinal & Gen Surg, Chelmsford, Essex, England

[2] ELPEN Pharmaceut, Expt Res Ctr, Athens, Greece

[3] Univ Athens, Laiko Gen Hosp, Dept Surg 1, Athens, Greece

[4] Democritus Univ Thrace, Fac Med, Dept Histopathol, Alexandroupolis, Greece

[5] Democritus Univ Thrace, Fac Med, Lab Expt Surg & Surg Res, Alexandroupolis, Greece

来源：

IN VIVO | 2019年 / 33卷 / 04期

关键词：

Apigenin; TNF-alpha; acute pancreatitis; biliopancreatic duct ligation; KAPPA-B; NECROTIZING PANCREATITIS; INFLAMMATORY RESPONSE; GENE-EXPRESSION; CYTOKINES; RATS; RESVERATROL; INHIBITION; ACTIVATION; INFLIXIMAB;

D O I：

10.21873/invivo.11583

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: This study investigated the anti-inflammatory effect of apigenin in an experimental model of acute pancreatitis. Inflammatory response was reflected by tissue expression of the cytokine TNF-alpha coupled with histological examination. Materials and Methods: Wistar rats were divided into three groups: Sham-group animals underwent laparotomy only, without any other interventions. Control-group animals underwent laparotomy and bilio-pancreatic duct ligation to induce pancreatitis without apigenin administration. Apigenin group animals were further treated with apigenin. Euthanasia was performed at 6, 12, 24, 48 and 72 h post-operatively. Results: Over-expression of TNF-alpha in relation to postoperative time was observed in the control group (p<0.001). In the apigenin group, under-expression of TNF-alpha in relation to postoperative time was observed (p<0.013). At 72 h, apigenin reduced pancreatic TNF-alpha expression and prevented pancreatic necrosis. Conclusion: Apigenin slows progression and reduces severity of acute pancreatitis. Apigenin may serve as an adjunct to a more successful therapeutic strategy in acute pancreatitis.

引用

页码：1133 / 1141

页数：9

共 47 条

[1] Elucidating the role of oxidative stress in the therapeutic effect of rutin on experimental acute pancreatitis [J].