Synthesis, Characterization and Molecular Docking Studies of 4-(5-Alkylsulfanyl-(1,3,4)oxadiazol-2-yl methyl)-7-methyl chromene-2-ones

被引：0
|
作者：
Gaddam, Ganga Reddy [1 ]
Sudugu, Ramakrishna Reddy [1 ]
Chittireddy, Venkata Ramana Reddy [1 ]
Bireddy, Srinivasa Reddy [2 ]
Eppakayala, Laxminarayana [3 ]
机构：
[1] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad, Telangana, India
[2] Mahatma Gandhi Inst Technol, Dept Chem, Hyderabad, Telangana, India
[3] Sreenidhi Inst Sci & Technol Autonomous Yamnampet, Dept Chem, Hyderabad, Telangana, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 32卷 / 04期
关键词：
DERIVATIVES; 1,3,4-OXADIAZOLES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 4-(5-alkylsulfanyl-[1,3,4]oxadiazol-2-ylmethyl)-7-methyl-chromen-2-ones (5a-d) was synthesized from (7-methyl-2-oxo-2H-chromen-4-yl)-acetic acid (1) as starting material. The structures of the synthesized new compounds were confirmed by their H-1-NMR, IR, and mass spectral data. The molecular docking studies of the compounds have been carried out to predict the possible anti-depressant activity.
引用
收藏
页码：449 / 453
页数：5
相关论文
共 50 条
  • [41] Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-ones as cisplatin sensitizers
    Hou, Xueyan
    Luo, Hao
    Zhang, Mengqi
    Yan, Guoyi
    Pu, Chunlan
    Lan, Suke
    Li, Rui
    MEDCHEMCOMM, 2018, 9 (11) : 1949 - 1960
  • [42] Synthesis and Characterization of Some New4-Methyl-N-{4-[6-(substituted aryl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]-phenyl}-benzenesulfonamides
    Al-Hamad, Maha A.
    Al-Sabawi, Ammar H.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2023, 33 (01) : 109 - 113
  • [43] One pot synthesis of 4-(arylidene)-2-[5-(4-hydroxy-6-methyl-2-oxo-2H-pyran3-yl)-thiazol-2-yl]-5-methyl-2,4-dihydro-pyrazol-3-ones via multi-component approach
    Aychiluhim, Tewodros Birhanu
    Penta, Santhosh
    Rao, Vedula Rajeswar
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2014, 53 (10): : 1242 - 1246
  • [44] Design, Synthesis, Molecular Docking and Biological Evaluation of Novel 2-[(2-{[5-(Pyridin-4-yl)-1, 3, 4-Oxadiazol-2-yl]Sulfanyl}Ethyl)Sulfanyl]-1,3-Benzoxazole
    Fathima, Anees
    Vagdevi, H. M.
    Jayanna, N. D.
    Shafeeulla, R. Mohammed
    Subbaraju
    JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2021, 33 (44A) : 472 - 484
  • [45] Synthesis, characterization and antibacterial activity of 2-[1-(5-chloro-2-methoxy-phenyl)-5-methyl-1H-pyrazol-4-yl]-5-(substituted-phenyl)- [1,3,4]oxadiazoles
    Rai, Neithnadka Premsai
    Narayanaswamy, Venugopala Katharigatta
    Shashikanth, Sheena
    Arunachalam, Pirama Nayagam
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) : 4522 - 4527
  • [46] Synthesis and Anticonvulsant Potential of Some New 4-[5-substituted-[1,3,4] oxadiazole-2-yl]-2-phenylquinolines
    Kumar, Rajnish
    Abdullah, Mohammad Mustqeem
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 29 (01) : 79 - 86
  • [47] Synthesis, evaluation of antimicrobial activity, and molecular modeling of novel 2-((4-(2H-benzo[d] [1,2,3] triazol-2-yl)piperidin-1-yl)methyl)-5-substituted phenyl-1,3,4-oxadiazoles
    Vankadari, Srinivas Rao
    Mandala, Devender
    Pochampalli, Jalapathi
    Tigulla, Parthasarathy
    Valeru, Anil
    Thampu, Rajakomuraiah
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (12) : 5912 - 5919
  • [48] Synthesis of 2-([5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents
    Ramzan, Muhammad S.
    Abbasi, Muhammad A.
    Aziz-ur-Rehman
    Siddiqui, Sabahat Z.
    Shah, Syed A. A.
    Ashraf, Muhammad
    Lodhi, Muhammad A.
    Khan, Farman A.
    Mirza, Bushra
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (05) : 913 - 926
  • [49] Synthesis, Crystal Structure and Fungicidal Activity of 3-Chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2H-chromen-2-ones
    Lv You
    Li Kun
    Hao Ze-Sheng
    Kalinina, Tatiana A.
    Glukhareva, Tatiana, V
    Fan Zhi-Jin
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2021, 40 (08) : 1068 - 1074
  • [50] Synthesis and Anticancer Activity Evaluation of (E)-3-{[5-(Aryl)-1,3,4-oxadiazol-2-yl]methyl}-5-(3,4,5-trimethoxybenzylidene)thiazolidine-2,4-diones
    Ashok, D.
    Vanaja, B.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (03) : 681 - 685
12345